Figure 1.

Evaluation of open modification search tools for xenobiotic-protein adduct discovery. Precision recall plot of adduct masses at 1% FDR by 7 open search algorithms. Closed comet searches using defined modifications were included as a positive control. Magnum was run allowing for open-masses on any amino acid (Magnum) or restricted to lysine only (Magnum K), the previously published residue modified by dicloxacillin and flucloxacillin adducts.^31,37