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. 2022 Feb 11;119(9):e2119995119. doi: 10.1073/pnas.2119995119

Fig. 2.

Fig. 2.

Glycosylation affected the specificity of elicited antibodies and the breadth of mRNA vaccine protection. The (A) alpha, (B) beta, (C) gamma, and (D) delta S protein–specific IgG antibody endpoint titers determined by ELISA. Neutralization curves of pseudovirus variants are shown with (E) WT, (F) alpha, (G) beta, (H) gamma, (I) delta, and (J) omicron. (K) The S protein 3D image of SARS-CoV-2 colored by conserved residues. Red, conserved and exposed residues (not shielded by glycans); yellow, conserved and exposed residues (shielded by glycans); green, buried residues; dark gray, mutation sites (mutation rate > 0.05%); light gray, nonemphasized regions. A–J show mean ± SD for five independent experiments. *P < 0.001, **P < 0.05.