Table 3.
Predictors of Virological Treatment Failure Using Bivariable and Multivariable Cox Regression Analysis Among Adolescent and Adult ART Clients in Southeast Ethiopia (n = 641)
| Variables | Characteristics | Binary Cox-Regression | Multiple Cox-Regression | ||
|---|---|---|---|---|---|
| P value | CHR (95%) | P-value | AHR (95%) | ||
| Baseline functional status | Working | ||||
| Ambulatory | 0.007 | 0.541(0.347–0.842) | 0.543 | 0.862(0.534–1.392) | |
| Bedridden | 0.045 | 2.189(1.019–4.699) | 0.209 | 1.698(0.744–3.879) | |
| WHO stage at ART initiation | Stage I | ||||
| Stage II | 0.001 | 3.088(1.795–5.312) | 0.025 | 1.960(1.086–3.537) | |
| Stage III | 0.001 | 3.391(2.033–5.657) | 0.004 | 2.323(1.317–4.098) | |
| Stage IV | 0.001 | 7.091(3.474–14.476) | 0.001 | 4.616(2.136–9.974) | |
| WHO stage during data collection | Stage I | ||||
| Stage II | 0.389 | 1.445(0.626–3.336) | 0.351 | 1.503(0.639–3.533) | |
| Stage III | 0.001 | 5.637(3.925–8.875) | 0.001 | 3.309(1.884–5.813) | |
| Stage IV | 0.001 | 7.789(3.861–15.716) | 0.016 | 3.054(1.227–7.600) | |
| Opportunistic infection | Yes | 0.001 | 2.116(1.466–3.055) | 0.127 | 0.675(0.408–1.118) |
| Drug toxicity | Yes | 0.004 | 1.814(1.205–2.730) | 0.263 | 1.303(0.819–2.073) |
| Adherence | Good | ||||
| Fair | 0.001 | 3.680(2.505–5.407) | 0.006 | 2.058(1.234–3.432) | |
| Poor | 0.001 | 5.534(2.534–12.119) | 0.008 | 3.097(1.349–7.108) | |
Abbreviations: CHR, crude hazard ratio; AHR, adjusted hazard ratio; WHO, World Health Organization.