Table 2.

Incidence rate ratios of dementia in people with and without HIV, overall and by time period – Kaiser Permanente, 2000–2016

	With HIV		Without HIV		Incidence rate ratio (95% CI)
Time period	Cases of dementia	Person-years of follow-up	Cases of dementia	Person-years of follow-up	Unadjusted	Adjusted^a
2000–2002	27	3,856	113	53,811	3.33 (2.19–5.08)	2.54 (1.60–4.05)
2003–2004	43	4,672	153	67,184	4.04 (2.88–5.67)	3.66 (2.58–5.19)
2005–2006	35	6,208	173	84,055	2.74 (1.90–3.94)	2.37 (1.63–3.45)
2007–2008	38	7,611	198	101,770	2.57 (1.81–3.63)	2.04 (1.43–2.91)
2009–2010	41	9,001	275	119,727	1.98 (1.43–2.75)	1.64 (1.16–2.31)
2011–2012	45	10,806	313	143,169	1.90 (1.39–2.60)	1.69 (1.23–2.32)
2013–2014	45	12,947	393	168,466	1.49 (1.09–2.03)	1.24 (0.90–1.70)
2015–2016	52	15,236	388	196,300	1.73 (1.29–2.31)	1.58 (1.18–2.12)
Overall	326	70,337	2,006	934,482	2.16 (1.92–2.43)	1.80 (1.60–2.04)

Adjusted for current age, sex, race/ethnicity, neighborhood-level education, ever smoking, alcohol use disorder, other substance use disorder, cerebrovascular disease, peripheral vascular disease, coronary heart disease, heart failure, hypertension, dyslipidemia, diabetes mellitus, obesity, depression, and number of outpatient visits in the year before baseline.