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Metabolic regulation in Treg cells. (A) Regulatory T cells have a crucial role in establishing an IFN-γ-rich environment that activates Indoleamine 2, 3-dioxygenase (IDO)- and IDO+ dendritic cells (DCs), either by forward signaling to DCs or by direct production of the cytokine. (B) Cell-intrinsic metabolic programs and environmental factors that can modulate FOXP3 expression ultimately affect Treg cells fate.
