Table III.
Content of HYP, UA, BUN, Cr, and Kim-1 at every time point after infection (n=10, ± SD).
| Content | Group | 0.5 h | 1 h | 2 h | 4 h | 8 h | 16 h | 24 h |
|---|---|---|---|---|---|---|---|---|
| HYP in | Control | 0.575±0.074 | 0.574±0.036 | 0.569±0.049 | 0.582±0.056 | 0.570±0.041 | 0.586±0.063 | 0.569±0.084 |
| lung tissue (µg/mg) | Exposure | 0.593±0.122 | 0.693±0.106 | 0.699±0.082 | 0.726±0.147 | 0.629±0.123 | 0.632±0.096 | 0.625±0.056 |
| Serum UA | Control | 126.81±11.66 | 135.53±20.68 | 133.64±17.54 | 142.72±15.93 | 117.45±22.51 | 128.84±14.77 | 112.57±18.53 |
| (µmol/l) | Exposure | 209.46±47.08 | 304.86±128.86b | 330.03±87.32b | 220.82±71.86 | 218.80±65.73 | 255.45±115.75b | 267.49±87.76b |
| BUN | Control | 9.18±0.71 | 10.58±1.79 | 9.65±1.57 | 10.28±2.33 | 11.21±1.10 | 8.65±0.94 | 8.44±2.38 |
| (mg/dl) | Exposure | 23.53±2.40b | 23.88±3.09b | 22.12±3.26b | 17.81±2.83b | 26.01±5.35b | 23.43±2.66b | 21.87±3.09b |
| Serum Cr | Control | 29.43±9.67 | 27.57±7.64 | 33.21±6.82 | 31.19±8.03 | 26.90±9.46 | 35.17±6.86 | 30.33±8.07 |
| (µmol/l) | Exposure | 104.87±9.55b | 110.24±23.36b | 118.55±32.99b | 70.70±26.63b | 76.03±14.23b | 85.08±26.54b | 91.04±14.90b |
| Serum | Control | 2.21±0.38 | 2.17±0.17 | 2.30±0.28 | 2.22±0.42 | 2.19±0.16 | 2.14±0.37 | 2.24±0.26 |
| KIM-1 (ng/ml) | Exposure | 3.21±0.80a | 3.85±0.71b | 3.89±0.88b | 3.93±1.09b | 2.94±0.67 | 2.94±0.42 | 3.49±0.45b |
aP<0.05 and bP<0.01, compared with the control group. HYP, hydroxyproline; UA, uric acid; BUN, blood urea nitrogen; Cr, creatinine; KIM-1, kidney injury molecule-1.