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. 2022 Feb 24;47(4):81. doi: 10.3892/or.2022.8292

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Copyright: © Shan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Effects of VSCC-SCs, SCC-SCs and HDFs on RANKL expression in cancer and stroma areas in bone invasion regions of HSC-3 cells in vivo. (A) IHC was used to determine RANKL expression in cancer and stroma areas. (B) Semi-quantification of RANKL expression in different groups of HSC-3 cells. Data are shown as the median and IQR, n=4. Statistical analysis was performed by Kruskal-Wallis test followed by Dunn's test. ^nsP>0.05, *P<0.05, ***P<0.001, ****P<0.0001 vs. HSC-3 or as indicated. HDFs, human dermal fibroblasts; IHC, immunohistochemistry; RANKL, receptor activator of NF-κB ligand; SCC-SC, squamous cell carcinoma-associated stromal cells; VSCC-SC, verrucous squamous cell carcinoma-associated stromal cells.