Table 5.

Predictors of treatment response (absolute definition)

	Treatment response (absolute definition)
	Good (N = 134)	Poor (N = 27)	Absent (N = 50)	Total (N = 211)	Multivariate analysis
					ORa	P-value
Sex (female)*	89 (66%)	19 (70%)	39 (78%)	147 (70%)	0.24 [0.047; 1.05]	0.07
Age at attack*	36.7 (14.7)	46.3 (15.8)	38.7 (14.9)	38.4 (15.1)	1.01 [0.97; 1.06]	0.49
Serostatus***
AQP4+	67 (50%)	18 (67%)	36 (72%)	121 (57%)
MOG+***	55 (41%)	7 (26%)	5 (10%)	67 (32%)	0.048 [0.0041; 0.35]	0.008
DN	12 (9%)	2 (7%)	9 (18%)	23 (11%)	1.25 [0.20; 7.75]	0.81
Location profile*
Isolated myelitis	56 (42%)	22 (81%)	15 (30%)	93 (44%)
Isolated optic neuritis	50 (37%)	2 (7%)	21 (42%)	73 (35%)	2.56 [0.55; 12.1]	0.23
Neuromyelitis optica*	8 (6%)	1 (4%)	7 (14%)	16 (8%)	4.83 [0.83; 32.6]	0.089
Other	20 (15%)	2 (7%)	7 (14%)	29 (14%)	0.23 [0.0099; 1.99]	0.24
Nadir EDSS	5.04 (2.38)	6.11 (1.96)	4.46 (1.93)	5.04 (2.27)
Number of therapeutic lines	1.44 (0.678)	1.37 (0.688)	1.54 (0.706)	1.45 (0.685)
Treatments
Corticosteroids	124 (93%)	25 (93%)	47 (94%)	196 (93%)
PE	44 (33%)	10 (37%)	18 (36%)	72 (34%)
IVIG*	2 (1%)	0 (0%)	4 (8%)	6 (3%)
Delay (days) to first line*	12.8 (14.3)	16.4 (20.3)	17.3 (24.3)	14.3 (17.9)
Delay (days) to second line**	24.9 (19.8)	19.0 (9.50)	39.0 (27.6)	27.8 (22.1)
Delay (days) to third line	42.7 (19.6)	NA	82.3 (60.6)	53.5 (41.6)
Delay (days) to PE**	19.8 (14.8)	17.2 (7.79)	47.1 (41.1)	26.3 (26.4)	1.03 [1.01; 1.07]	0.024

Quantitative variables are presented as mean (SD). Categorical variables are presented as count (percentage)

DN double seronegative NMOSD attacks, EDSS Expanded Disability Status Scale, PE plasma exchanges, OR odds ratio, ORa adjusted odds ratio, NA not applicable

Univariate analysis: *p value < 0.2; **p value < 0.05; ***p value < 0.001