Figure 5.

PPI efficacy in children: histologic remission (<15 eos/hpf). The analysis was conducted using the R statistical package metafor,²¹⁰ assuming a fixed effects model and using inverse-variance weighting. The reported summary statistic is the back-transformed inverse-variance weighted average for histologic remission across all studies listed in children. References: Sayej, 2009,²¹ Dranove, 2009,²⁰ Schroeder, 2013,¹⁸⁵ Rea, 2013, Gutiérrez-Junquera, 2016,¹⁸⁷ Gómez-Torrijos, 2018,¹⁸⁸ Harris, 2018,²¹³ Vieira, 2020,¹⁸⁹ Rosen, 2021²¹⁴.

Abbreviations: Study Design: P, prospective study design; R, retrospective study design; PPI Type: E, esomeprazole; NR, not reported or any available; O, omeprazole; P, pantoprazole; Dose: BID, two times a day; kg, kilogram; mg, milligram; NR, not reported; Duration: NR, not reported; wk, week.