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. Author manuscript; available in PMC: 2022 Jul 17.
Published in final edited form as: Nat Metab. 2022 Jan 17;4(1):44–59. doi: 10.1038/s42255-021-00515-3

Fig. 2. Obesity induces HDAC6 activity in the adipose tissue.

Fig. 2.

a, HDAC6 mRNA expression at the indicated tissues collected from lean and DIO wild-type mice fed ad lib or fasted overnight (n=5 for liver and hypothalamus of lean fed and muscle of lean fasted; n=6 for all other groups). *P<0.05, **P<0.01 as analyzed by one-way ANOVA. b-d, Representative immunoblots of tissue lysates from the white adipose tissue (WAT), liver and the hypothalamus of lean and DIO wild-type or HDAC6 KO mice. The western blots were reproduced in at least two cohorts. Quantifications are graphed on the right of western blots (n=20, c P=8.1E-11; n=6, d and e, by two-tailed unpaired t-test) ***P<0.001 as analyzed by two-tailed Student’s t-test. Data are represented as mean ± s.e.m.