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. 2022 Feb 18;7(8):7155–7171. doi: 10.1021/acsomega.1c06836

Table 4. IC50 Values Obtained Due to In Vivo p53 Ubiquitination Inhibition of MCF-7 Cells.

  IC50 (mean ± SEM) (nM)
compound no. p53 ubiquitination
DPI 0.26 ± 0.005
5a 0.68 ± 0.01
5b 0.62 ± 0.05
5c 0.60 ± 0. 03
6a 0.59 ± 0. 01
6b 0.50 ± 0.05
6c 0.48 ± 0.02
7 0.48 0 ± 0.05