Table 4. IC50 Values Obtained Due to In Vivo p53 Ubiquitination Inhibition of MCF-7 Cells.
| IC50 (mean ± SEM) (nM) | |
|---|---|
| compound no. | p53 ubiquitination |
| DPI | 0.26 ± 0.005 |
| 5a | 0.68 ± 0.01 |
| 5b | 0.62 ± 0.05 |
| 5c | 0.60 ± 0. 03 |
| 6a | 0.59 ± 0. 01 |
| 6b | 0.50 ± 0.05 |
| 6c | 0.48 ± 0.02 |
| 7 | 0.48 0 ± 0.05 |