Fig. 2.

CpG content in SARS-CoV-2 genomes has stabilized with increasing number of infections: Number of SARS-CoV-2 sequences available on each day was determined along with the cumulative number of documented infections until the given day. Y axis on the right indicates the extent of reduction between minimum and maximum value of CpG metrics. Grids are colored orange and green to demarcate the total number of documented infections into the first one-third and the subsequent two-thirds, respectively. The line graphs indicate that majority (∼>85%) of the CpG depletion in the SARS-CoV-2 genomes occurred well before the first one-third (orange grid) of documented infections (i.e., 56.92 million infections corresponding to November 2020). The CpG content appears to be stabilized in the green part (i.e., during the subsequent 113.87 million infections) indicated by almost constant values.