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. 2022 Feb 3;39(3):msac029. doi: 10.1093/molbev/msac029

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 8. — The changing dynamics of CpG depletion in SARS-CoV-2 genomes over time: a schematic representation highlighting the differences in the dynamics of CpG depletion during evolution of SARS-CoV-2 in humans. Adaptive evolution of bat coronaviruses has been linked to CpG depletion prior to infecting humans. The selection pressures leading to further CpG deletion during early evolution in humans are indicated. The CpG content of SARS-CoV-2 appears to have stabilized and reached an equilibrium following early evolution in humans. SARS, severe acute respiratory syndrome; CoV, coronavirus; ZAP, zinc-finger antiviral protein; APOBEC, apolipoprotein B mRNA-editing catalytic polypeptide.