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Design of CL11 variant libraries. Crystal structure of the CL11–58rRNA complex: (A) CL11: gray cartoon; CL11 substitution spots late to early amino acids: blue sticks; 58rRNA: green surface; (B) CL11: gray cartoon; CL11 substitution spots late to mid-stage amino acids: orange sticks; 58rRNA: green surface; (C) Randomization scheme for the CL11 -E and -M libraries.
