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Selection of the CL11 variant libraries. The library E (A) and M (B) randomized fragment (1–69) sequencing results of the rounds 6, 9, 11, 14, and 16 and 1, 4, 6, and 10, respectively, displayed as sequence logos generated from 100 most abundant protein sequences in each selection round. The residue color code is based on amino acid charge (negatively charged: red, positively charged: blue and others: black).
