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. Author manuscript; available in PMC: 2023 Mar 5.
Published in final edited form as: Eur J Med Chem. 2022 Jan 10;231:114103. doi: 10.1016/j.ejmech.2022.114103

Scheme 2.

Scheme 2.

Synthesis of 7-deaza (N)-methanocarba nucleoside 5’-esters 61 – 64. Reagents and conditions: (i) Ph(CH2)3NH2, DIPEA, 2-propanol, 69–72%; (ii) arylalkyne, PdCl2(Ph3P)2, CuI, Et3N, DMF, rt, 67–72%; (iii) 10% TFA, MeOH, 70 °C, 88–91%.