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. 2022 Feb 1;130(5):694–707. doi: 10.1161/CIRCRESAHA.121.319874

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© 2022 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 2. — GLP1 (glucagon like-peptide 1) receptors are expressed in chemosensory glomus cells of the carotid body. A and B, GLP1R (glucagon like-peptide 1 receptor) were found to be present in the chemosensory glomus cells as shown by cross-immunoreactivity with glomus cell marker (TH). GLP1R was also expressed in a subset but not all blood vessels associated with tomato lectin/lycopersicon esculentum lectin (TL/LEL) signal in WKY carotid bodies (CBs). C and D, CBs of SH rats contained no GLP1R-immunoreactive blood vessels while expression in the chemosensory component was retained. E, Diagram summarizing GLP1R localization in rat CBs. In WKY, GLP1R is localized in chemosensory glomus cells and a subset but not all blood vessels. In SH rats, GLP1R is retained in the chemosensory component but is lost from the vascular component. Representative images selected based on GLP1R localization across all WKY and SHR samples (Figure S4). Magnified panels selected to highlight differences in GLP1R localization between WKY and SHR. Arrowheads—blood vessels expressing GLP1R; Arrows—blood vessels not expressing GLP1R. Images representative of n=3. Scale bar—20 µm. DAPI indicates 4′,6-diamidino-2-phenylindole; and TH, tyrosine hydroxylase.