Table 2.
Top 10 Up-Regulated and Down-Regulated Proteins Between Delirium Cases and Controls at POD2a
| Protein Name | Entrez Gene ID |
Entrez Gene Symbol | p Value | tFC (DEL/CNT) |
|---|---|---|---|---|
| Up-Regulated/Increased in Delirium | ||||
| Phospholipase A2; membrane associated | 5320 | PLA2G2A | .0450 | 1.94 |
| Interleukin-6 | 3569 | IL6 | .0047 | 1.90 |
| MHC class I polypeptide-related sequence A | 4276 | MICA | .0128 | 1.79 |
| Metalloproteinase inhibitor 1 | 7076 | TIMP1 | .0031 | 1.74 |
| Thrombospondin-1 | 7057 | THBS1 | .0220 | 1.69 |
| CD177 antigen | 57126 | CD177 | .0092 | 1.68 |
| Pituitary adenylate cyclase-activating polypeptide 27 | 116 | ADCYAP1 | .0142 | 1.63 |
| Chitinase-3-like protein 1 | 1116 | CHI3L1 | .0049 | 1.60 |
| Creatine kinase M-type | 1158 | CKM | .0448 | 1.54 |
| CMRF35-like molecule 6 | 10871 | CD300C | .0183 | 1.53 |
| Down-Regulated/Decreased in Delirium | ||||
| Protein amnionless | 81693 | AMN | .0364 | −1.33 |
| Syntaxin-1A | 6804 | STX1A | .0455 | −1.33 |
| C-C motif chemokine 16 | 6360 | CCL16 | .0450 | −1.34 |
| Choline/ethanolamine kinase | 1120 | CHKB | .0328 | −1.34 |
| Plasma protease C1 inhibitor | 710 | SERPING1 | .0033 | −1.35 |
| Melanoma-derived growth regulatory protein | 8190 | MIA | .0190 | −1.37 |
| C-C motif chemokine 27 | 10850 | CCL27 | .0366 | −1.38 |
| Cadherin-1 | 999 | CDH1 | .0047 | −1.39 |
| Angiostatin | 5340 | PLG | .0043 | −1.39 |
| Leucine-rich repeats and immunoglobulin-like domains protein 3 | 121227 | LRIG3 | .0024 | −1.39 |
Note: CNT = No delirium control; DEL = Delirium case, tFC = Tukey’s fold change.
aTop proteins selected based on Tukey’s fold change.