TABLE 1.

Exploratory activity of rats treated with Galanin 2 receptor agonist (M1145) and the Neuropeptide Y Y1 receptor (NPY Y1) agonist alone and in combination. Data are expressed as mean ± SEM from the training and test sessions during the Object-in-place task. For total exploration time in training and test sessions no statistically significant difference was observed between the experimental groups according to one way ANOVA. && p < 0.01 according to one-way ANOVA followed by Newman-Keuls post-hoc test for relocated objects time of M1145 + Y1R group compared with the rest of the groups. ***p < 0.001 (two-tailed paired t-test) Familiar vs. Relocated. Abbreviations: Control = Distilled water; M1145 = Galanin 2 receptor agonist 132 µg; Y1R = Y1R receptor agonist [Leu³¹-Pro³⁴]NPY 132 µg; M1145 + Y1R = Coadministration of M1145 and Y1R; M1145 + Y1R + M871 = Coadministration of M1145, Y1R and GALR2 antagonist M871 132 µg.

Group	Control	M1145	Y1R	M1145 + Y1R	M1145 + Y1R + M871
Training [Total exploration time (s)]	20.6 ± 0.8	21 ± 0.4	21.4 ± 0.8	21 ± 0.6	22 ± 1.1
Test [Total exploration time (s)]	19.8 ± 1.6	18.2 ± 1.1	20.1 ± 0.9	22.3 ± 1.2	19.3 ± 0.9
Familiar Objects (s)	7.7 ± 0.8	7.1 ± 0.7	7.4 ± 0.5	6.9 ± 0.5	7.4 ± 0.5
Relocated objects (s)	12.1 ± 0.8***	11 ± 0.4***	12.7 ± 0.6***	15.4 ± 0.8***&&	11.9 ± 0.7***