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. 2022 Feb 17;13:838328. doi: 10.3389/fimmu.2022.838328

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Copyright © 2022 Trevelin, Pickering, Todd, Bishop, Pitcher, Garrido Mesa, Montorsi, Spada, Petrov, Green, Shankar-Hari, Neil and Spencer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased memory and antigen-presenting B cells in ileal follicles in Peyer’s patches (PP) of COVID-19 patients. (A) Representative images from histoCAT showing CD27 (green) and CD20 (red) in ileal follicles in Peyer’s Patch (PP) from COVID-19^- and COVID-19⁺ patients on the top. The percentage of CD27⁺CD20⁺ cells and mean signal of CD27 in B cells on the bottom. (B) Representative images from histoCAT showing CD74 (green) and CD20 (red) in ileal follicles on the top. The percentage of CD74^hiCD20⁺ cells and mean signal of CD74 in B cells on the bottom. (C) Representative images from histoCAT showing CD74 (green) and CD20 (red) in white pulp from spleen on the left. The percentages of CD74^hiCD20⁺ cells and mean signal of CD74 in B cells on the right. Two tailed Mann-Whitney t test. *P < 0.05.