Table 2.
Comparison of Gait, Cognitive, and Neuroimaging Measures at Baseline (2011) and Follow-up (n = 217)
| Gait and Cognitive Measures | Baseline (2011) | Follow-up (2015) | p-value |
|---|---|---|---|
| TUG time, seconds (mean [SD]) | 9.14 (1.60) | 10.07 (1.76) | <.001 |
| TUG steps, n (mean [SD]) | 12.42 (1.70) | 13.66 (2.09) | <.001 |
| Gait impairment, n (%) | 10 (4.6) | 27 (12.4) | <.001 |
| Cognitive index (mean [SD]) | 0.28 (0.65) | 0.23 (0.68) | .015 |
| Executive function (mean [SD]) | 0.24 (0.70) | 0.22 (0.69) | .445 |
| Psychomotor speed (mean [SD]) | 0.32 (0.74) | 0.27 (0.76) | .022 |
| Neuroimaging measures | |||
| Global efficiency (mean [SD]) | 10.68 (2.26) | 10.60 (2.39) | .166 |
| WMH, mL (median [IQR]) | 2.50 [1.14, 6.53] | 3.85 [1.76, 9.20] | <.001 |
| Lacunes presence, n (%) | 26 (12.0) | 48 (22.1) | <.001 |
| Microbleeds presence, n (%) | 38 (17.5) | 48 (23.0) | .067 |
| TBV, mL (mean [SD]) | 1 096.38 (123.09) | 1 074.54 (125.78) | <.001 |
Notes: Data represent number of participants (%), mean ± SD or median (IQR). TBV = total brain volume; WMH = white matter hyperintensity.