Abstract
There has been an increase in the prevalence of cardiovascular diseases among young adults in the United States that has been attributed, in part, to a rise in overweight and obesity, use of combustible tobacco and unhealthy diet and exercise patterns. These factors are influenced further by socioeconomic status and other social determinants of health. In the My Research Legacy study, we examined ideal cardiovascular health in young adults aged 18– <50 years with cardiovascular disease using the Life's Simple 7 survey and data from digital health devices. Young adults with cardiovascular disease (n = 349) were older, had a lower socioeconomic status, a higher prevalence of risk factors, and lower Life's Simple 7 Health Scores (6.4 ± 1.5 vs. 7.1 ± 1.5, p < 0.01) compared to young adults without cardiovascular disease (n = 696). Analysis of digital health device data revealed that young adults with cardiovascular disease performed a similar number of weekly minutes of moderate and vigorous exercise as those without disease leading to similar ideal activity scores. Young adults with cardiovascular disease also shared similarities in modifiable risk factors with adults aged ≥50 years with cardiovascular disease (n = 217), including weight, dietary habits, and weekly minutes of exercise. Latent class analysis identified two phenogroups of young adults with cardiovascular disease: phenogroup 1 was characterized by more advantageous cardiovascular health factors and behaviors resulting in higher Life's Simple 7 Health Scores than phenogroup 2 (7.4 ± 1.2 vs. 5.5 ± 1.1, p < 0.01). These findings in young adults with cardiovascular disease may inform the design of behavioral and therapeutic interventions in the future to decrease cardiovascular morbidity and mortality.
Keywords: cardiovascular disease in the young, ideal cardiovascular health, surveys, digital health devices, direct to participant research
Introduction
Although there has been a significant decline in mortality attributable to cardiovascular diseases, there is accumulating evidence that this benefit may be age-specific and less applicable to younger patients (1, 2). Reports have noted an increasing prevalence of cardiovascular diseases in individuals under the age of 55 years, including higher rates of myocardial infarction and stroke (3–5). The etiology of the rise in cardiovascular diseases in younger adults is multifactorial and has occurred concomitant with an increase in the proportion of populations that are overweight and obese; have prevalent hypertension, hyperlipidemia, and diabetes mellitus; continue to use combustible tobacco and e-cigarette products; and consume highly processed foods (6–9). These health factors and habits are influenced further by racial and ethnic, socioeconomic, and gender disparities resulting in a higher incidence and prevalence of cardiovascular disease in select community-based populations (7, 9, 10).
The American Heart Association has prioritized achieving ideal cardiovascular health for all as a 2,030 strategic impact goal with a focus on increasing health equity among populations, overall community, and individual well-being, and decreasing cardiovascular mortality (11, 12). The American Heart Association assesses ideal cardiovascular health as a composite of modifiable health behaviors (exercise, diet, tobacco use) and health factors (weight, blood pressure, cholesterol, fasting blood glucose) (13). The importance of achieving and maintaining ideal cardiovascular health has been confirmed by observational studies that associated it with a lower incidence of cardiovascular disease and mortality (14–18). Despite this, ideal cardiovascular health has declined over the past 20 years in communities (16, 18) and an analysis from the National Health and Nutrition Examination Survey (NHANES) estimated that ~70% of all cardiovascular disease events were related to non-ideal cardiovascular health (19).
Among young adults aged 20–49 years in NHANES, analysis of ideal cardiovascular health habits and behaviors reported that the percentage of individuals with non-ideal scores for BMI, physical activity, or healthy diet was ≥50%. Although the percentage of individuals with non-ideal scores for smoking, cholesterol, blood pressure, or fasting blood glucose levels was ≤ 45%, there was no single Life's Simple 7 health factors or habits category where all individuals achieved an ideal score (20). In the current study, we examined ideal cardiovascular health in young adult participants (age <50 years) in the American Heart Association's My Research Legacy study. Since our study sample was enriched for individuals with established cardiovascular disease, we hypothesized that young adults with cardiovascular diseases would represent a heterogeneous group with differences in ideal cardiovascular health factors and habits compared to young adults without cardiovascular disease.
Methods
Study Cohort
The My Research Legacy study (NCT 02958098) was a direct-to-participant study sponsored by the American Heart Association that was open for enrollment between November 2016 and October 2018 (21). The study was approved by the Advarra Institutional Review Board (#31995) and all participants signed informed consent. Participants were eligible for the study if they resided in the United States, were ≥18 years old and had internet access. Baseline demographics were self-reported. History of cardiovascular disease was broadly defined as prior myocardial infarction, stroke, atrial fibrillation, systolic heart failure, cardiomyopathy, and aortic dissection. Participants were considered to have prior cardiovascular disease if they responded affirmatively to a series of disease-specific questions that were derived by a panel of subject matter experts (Supplementary Table 1). The affluence index, a measure of socioeconomic status, was derived from the National Neighborhood Data Archive (https:openicpsr.org), which is based on zip code tabulation areas. This validated index ranges from 0 to 1.0 and is defined by an average of census indicators (college education, incomes >$75K, and managerial and professional occupations) (22). A zip code crosswalk was utilized to align the affluence index with participant zip codes (23).
Ideal Cardiovascular Health Assessment
Ideal cardiovascular health was assessed using the Life's Simple 7 survey (11, 13). This instrument includes questions related to cardiovascular health-related factors (weight, blood glucose, total cholesterol, and blood pressure levels) and behaviors (diet, exercise, combustible tobacco use). Ideal cardiovascular health is assessed by assigning a score of 0, 1, or 2 (poor, intermediate, or ideal, respectively) for each of the 7 cardiovascular health and habit categories according to prespecified criteria. A final Health Score that incorporates medication used to manage cardiovascular disease risk factors is calculated and can range between 0 (poor) and 10 (ideal). A state of ideal cardiovascular health was defined by having an overall Health Score of >7.0 or by meeting ideal criteria (category score = 2) for a minimum of 5 categories (12, 24).
Digital Health Device Data
A subset of participants either registered their own digital health device with the study or were provided with a Fitbit Charge 2 device (25). Individuals with digital scales linked them to their devices to capture weight data. Digital health data were uploaded in 24-h increments to Validic (Validic Inc., Durham, NC). Deidentified data were parsed into weight, fitness, and routine categories using device-specific algorithms via the Validic API and transmitted to secure severs that were managed by The Broad Institute (Cambridge, MA) and REAN Cloud LLC (Herndon, VA).
Latent Class Analysis
A series of latent class models were fitted using the Life's Simple 7 health and habit data for participants aged <50 years with cardiovascular disease. Latent class analysis is a probabilistic clustering methodology that assumes that within a population there are latent or unmeasured classes and that the relationship between any two variables is explainable by the latent variables (26). This model-based clustering approach has been used to identify clusters of individuals with cardiovascular disease and assign an individual to a class (or cluster) where that individual has the greatest probability of membership (27–30). Latent class analysis uses item-response probability, which is the probability that a variable is conditional for class membership, to identify the distinctness of each class (28–30). Model fitting is performed using the maximum likelihood method and several models are generated to determine the model with the optimum number of classes (or clusters) that adequately describes the dataset. Analyses are conducted in a stepwise manner starting with a 1-class model and the number of classes is increased with each iteration (30). The optimum number of classes was based on the criteria for model selection, which included the Bayesian Information Criteria, Vuong-Lo-Mendell-Rubin likelihood ratio test and class size. Following model selection, participants were assigned to their class based on posterior probability (26). The analyses were performed using MPlus (version 8.6, Muthén & Muthén, Los Angeles, CA).
Sample Size Calculation and Statistical Analysis
The sample size to ensure that young adults with cardiovascular disease were represented adequately in the analyses was calculated based on the study enrollment of 1,561 participants with complete Life's Simple 7 survey data. With a prevalence of cardiovascular diseases of 40% in young adults aged <50 years (24), to achieve 95% power with an alpha = 0.05, the minimum sample size of young adults with cardiovascular disease required was 299 participants. For older adults aged ≥50 years, with a prevalence of cardiovascular diseases of 70% (24) to achieve 90% power with an alpha = 0.05, the minimum sample size required was 199 participants.
Data are presented as mean ± SD and p-values < 0.05 were considered significant. Normality of the data was tested using the Shapiro-Wilk test. Comparisons between continuous variables with normal distributions were analyzed using t-tests. Comparisons between categorical variables were analyzed using the chi-square test or Fisher's exact test as applicable. Non-parametric testing was done using the Wilcoxon-rank sum test. Propensity score matching was performed to compare young adults with prior myocardial infarction or cardiomyopathy/systolic heart failure to young adults without cardiovascular disease who had similar characteristics. Propensity score matching was done using a logit model that was adjusted for age, gender, race and ethnicity, and region at a ratio of 1:1. Data were analyzed using Stata 15/SE 15.1 (StataCorp LLC, College Station, TX) and Prism 9.0 (GraphPad, San Diego, CA).
Results
Ideal Cardiovascular Health in Young Adults With vs. Without Cardiovascular Disease
The My Research Legacy study enrolled 1,045 individuals aged <50 years of whom 349 had prior cardiovascular disease and 696 had no prior history of cardiovascular disease. Among the 349 individuals with established cardiovascular disease, 63 participants had a prior stroke, 130 participants had a prior myocardial infarction, 107 participants had cardiomyopathy and/or systolic heart failure, 13 had an aortic dissection, and 52 had atrial fibrillation. Sixteen participants had more than one diagnosis.
Young adults with cardiovascular disease were slightly older (39.8 ± 6.7 vs. 35.3 ± 8.4 yrs, p < 0.01), more likely to be Black, Asian, or Hispanic race and ethnicity and had a lower affluence index compared to individuals without cardiovascular disease (Table 1). Participants with cardiovascular disease were more likely to be current or prior smokers and had a higher prevalence of diabetes mellitus, hypertension, and hypercholesterolemia as well as medication use for these comorbidities compared to individuals without cardiovascular disease (all p < 0.01). Weight and body mass index (31.4 ± 8.7 vs. 29.3 ± 8.0 kg/m2, p < 0.01) and blood glucose levels (p < 0.01) were higher in young adults with cardiovascular disease compared to those without disease, but total cholesterol levels were lower (p < 0.05).
Table 1.
Self-reported demographics, clinical, and Life's Simple 7 data for participants age <50 yrs.
| Age <50 years No CVD (n = 696) | Age <50 yrs CVD (n = 349) | P-value | |
|---|---|---|---|
| Age (yrs) | 35.3 ± 8.4 | 39.8 ± 6.7 | <0.01 |
| Gender (no., % female) | 572 (82.2) | 293 (84.0) | 0.48 |
| Race and ethnicity (no.) | |||
| Asian | 26 | 5 | <0.02 |
| Black | 20 | 21 | |
| Hispanic | 39 | 16 | |
| White | 590 | 290 | |
| Other | 21 | 17 | |
| Region (no.) | |||
| Northeast | 104 | 59 | 0.31 |
| South | 264 | 147 | |
| Midwest | 175 | 75 | |
| West | 153 | 68 | |
| Affluence status | 0.43 ± 0.15 | 0.39 ± 0.14 | <0.01 |
| ASCVD risk factors | |||
| Diabetes mellitus (no., %) | 35 (5.0) | 53 (15.2) | <0.01 |
| Hypertension (no., %) | 244 (35.1) | 210 (60.2) | <0.01 |
| Hypercholesterolemia (no., %) | 234 (33.6) | 201 (57.6) | <0.01 |
| Medications (no., %) | |||
| Diabetes mellitus | 28 (4.0) | 46 (13.2) | <0.01 |
| Hypertension | 99 (14.2) | 167 (47.9) | <0.01 |
| Hypercholesterolemia | 32 (4.6) | 101 (28.9) | <0.01 |
| Smoking status (no., %) | |||
| Current | 49 (7.0) | 38 (10.9) | <0.01 |
| Quit ≤ 1 year | 16 (2.3) | 32 (9.2) | |
| Quit >1 year | 124 (17.8) | 106 (30.4) | |
| Never | 507 (72.9) | 173 (49.5) | |
| Clinical data | |||
| Weight (kg) | 82.5 ± 24.2 | 87.9 ± 26.1 | <0.01 |
| BMI (kg/m2) | 29.3 ± 8.0 | 31.4 ± 8.7 | <0.01 |
| Systolic blood pressure (mmHg)* | 116.4 ± 10.5 | 116.5 ± 14.9 | 0.98 |
| Diastolic blood pressure (mmHg)* | 73.3 ± 7.5 | 72.6 ± 10.2 | 0.25 |
| Total cholesterol (mmol/L)* | 187.9 ± 22.4 | 184.6 ± 29.1 | <0.05 |
| Blood glucose (mmol/L)* | 95.5 ± 16.2 | 99.9 ± 20.8 | <0.01 |
| Diet | |||
| Vegetables/day (cups) | 1.8 ± 1.3 | 1.9 ± 1.3 | 0.79 |
| Fruit/day (cups) | 1.4 ± 1.1 | 1.4 ± 1.1 | 0.83 |
| Fish (servings/week) | 0.8 ± 1.0 | 0.9 ± 1.0 | 0.27 |
| Whole grains (servings/day) | 1.8 ± 1.3 | 1.5 ± 1.1 | <0.01 |
| Sugar-sweetened beverages (servings/week) | 2.8 ± 3.5 | 2.7 ± 3.4 | 0.83 |
| Avoid prepackaged foods (no., %) | 311 (44.7) | 193 (55.3) | <0.01 |
| Avoid eating out (no., %) | 212 (30.5) | 167 (47.9) | <0.01 |
| Avoid salt at home (no., %) | 308 (44.3) | 246 (70.5) | <0.01 |
| Exercise | |||
| Moderate exercise (min/week) | 198.5 ± 211.9 | 215.5 ± 236.5 | 0.24 |
| Vigorous exercise (min/week) | 76.5 ± 118.1 | 53.8 ± 107.3 | <0.01 |
| Life's Simple 7 | |||
| Smoking score (no., %) | <0.01 | ||
| Poor | 49 (7.0) | 38 (10.9) | |
| Intermediate | 16 (2.3) | 32 (9.2) | |
| Ideal | 631 (90.7) | 279 (79.9) | |
| Activity score (no., %) | 0.08 | ||
| Poor | 14 (2.0) | 7 (2.0) | |
| Intermediate | 251 (36.1) | 146 (41.8) | |
| Ideal | 431 (61.9) | 196 (56.2) | |
| Diet score (no., %) | <0.01 | ||
| Poor | 348 (50.0) | 149 (42.7) | |
| Intermediate | 303 (43.5) | 163 (46.7) | |
| Ideal | 45 (6.5) | 37 (10.6) | |
| Weight score (no., %) | <0.01 | ||
| Poor | 270 (38.8) | 172 (49.3) | |
| Intermediate | 164 (23.6) | 81 (23.2) | |
| Ideal | 262 (37.6) | 96 (27.5) | |
| Blood glucose score (no., %) | <0.01 | ||
| Poor | 16 (2.3) | 23 (6.6) | |
| Intermediate | 123 (17.7) | 87 (24.9) | |
| Ideal | 557 (80.0) | 239 (68.5) | |
| Cholesterol score (no., %) | <0.01 | ||
| Poor | 14 (2.0) | 5 (1.4) | |
| Intermediate | 207 (29.7) | 192 (55.0) | |
| Ideal | 475 (68.3) | 152 (43.6) | |
| Blood pressure score (no., %) | <0.01 | ||
| Poor | 29 (4.2) | 25 (7.2) | |
| Intermediate | 261 (37.5) | 197 (56.5) | |
| Ideal | 406 (58.3) | 127 (36.4) | |
| LS7 Health Score | 7.1 ± 1.5 | 6.4 ± 1.5 | <0.01 |
*Contains imputed data from Life's Simple 7. Categorical variables are analyzed by Chi-Square test. Continuous variables are analyzed by t-test. Non-parametric variables were analyzed by Wilcoxon rank-sum test. CVD, cardiovascular disease; ASCVD, atherosclerotic cardiovascular disease.
There were also differences between young adults with and without prior cardiovascular disease with respect to other modifiable cardiovascular health behaviors, including diet and dietary habits as well as weekly minutes of exercise (Table 1). Individuals with cardiovascular disease consumed fewer whole grains (p <0.01) and were more likely to avoid prepackaged foods, eating out, or adding salt to their food than individuals without cardiovascular disease (all p < 0.01). While there was no difference between the groups with respect to minutes of moderate exercise per week, young adults with cardiovascular disease self-reported fewer minutes of vigorous exercise per week than individuals without cardiovascular disease (53.8 ± 107.3 vs. 76.5 ± 118.1 min/week, p < 0.01). Young adults with cardiovascular disease were less likely to have ideal scores in 5 or more Life's Simple 7 health factors and behaviors categories (Figure 1) and had lower Life's Simple 7 Health Scores than young adults without cardiovascular disease (6.4 ± 1.5 vs. 7.1 ± 1.5, p < 0.01) (Figure 1).
Figure 1.
Ideal cardiovascular health in participants aged <50 years old with and without cardiovascular diseases. (Left) The number of Life's Simple 7 health factor and behavior categories scored as ideal for young adults with cardiovascular disease (n = 349) compared to those without cardiovascular disease (n = 696). P < 0.01 by Wilcoxon rank-sum test. (Right) Life's Simple 7 Health Score in young adults with cardiovascular disease compared to those without cardiovascular disease. P < 0.01 by Wilcoxon rank-sum test.
Next, we examined ideal cardiovascular health in young adults with prior myocardial infarction in order to determine if our findings in young adults with the cardiovascular diseases included in our study were also observed when a single cardiovascular disease was considered. Young adults with prior myocardial infarction (n = 130) were compared to a matched sample of young adults without cardiovascular disease using propensity score matching that considered age, gender, race and ethnicity, and region in order minimize bias. After propensity score matching, the average effect of prior myocardial infarction on the Life's Simple 7 Health Score was a −0.8 (95% CI −1.1 to 0.4, p < 0.01) indicating that prior myocardial infarction was associated with a Health Score that was 0.8 points lower than that for a matched group of young adults without cardiovascular disease, similar to what was observed for the analysis that included young adults with any cardiovascular disease. A similar analysis was performed for young adults with cardiomyopathy/systolic heart failure (n = 107). After propensity score matching, the average effect of this cardiovascular disease was −0.7 (95% CI −1.1 to 0.4, p <0.01), indicating that the Health Score was decreased by 0.7 points in young adults with cardiomyopathy/systolic heart failure compared to matched young adults with no cardiovascular disease.
Young Adults With Cardiovascular Disease Share Similarities With Older Adults With Cardiovascular Disease
The study also enrolled 516 individuals aged ≥50 years of whom 217 had a history of cardiovascular disease. We next sought to determine if there were similarities in ideal cardiovascular health profiles between young and older adults (aged ≥50 years) with cardiovascular disease (Table 2). In our study, young adults were more likely to be female (84.0 vs. 67.3%, p < 0.01) and have a lower affluence index (p < 0.02) than older adults, but there were no differences between the groups with respect to race or ethnicity or geographic region. Younger adults were more likely to be current or former smokers than older adults (50.4 vs. 40.1%, p < 0.01), had a lower prevalence of hypertension (60.2 vs. 77.4%, p < 0.01) and hypercholesterolemia (57.6 vs. 83.0%, p < 0.01) than older adults, but were less likely to be taking medications for these conditions. Young adults also had lower systolic blood pressures (116.5 ± 14.9 vs. 120.6 ± 13.8 mmHg, p < 0.01) and fasting blood glucose levels (99.9 ± 20.8 vs. 106.8 ± 16.3 mg/dL, p < 0.01) compared to older adults with no differences in diastolic blood pressure or total cholesterol levels between the groups. There were no differences between the groups with respect to other modifiable risk factors, including weight and BMI and weekly minutes of moderate or vigorous exercise. There were few differences in dietary habits between the groups with the exception of servings of fish per week, which was lower in young adults (0.9 ± 1.0 vs. 1.1 ± 1.1 servings per week, p < 0.01), consumption of sugar-sweetened beverages, which was higher in young adults (2.7 ± 3.4 vs. 1.5 ± 2.8, p < 0.01), and the tendency to avoid preprocessed foods, which was lower in young adults (55.3 vs. 64.5%, p < 0.04). Despite the many similarities between the groups, the percent of young adults with ideal scores in each of the Life's Simple 7 health factors and behaviors categories was lower than older adults for smoking, activity, and diet and higher than older adults for glucose, total cholesterol, and blood pressure. There were no discernable differences between the groups with respect to weight (Figure 2). Nonetheless, young adults had higher Life's Simple 7 Health Scores (6.4 ± 1.5 vs. 6.0 ± 1.4 p < 0.01) than older adults.
Table 2.
Life's Simple 7 data for participants age <50 and ≥50 yrs with CVD.
| Age <50 yrs (n = 349) | Age ≥50 yrs (n = 217) | P-value | |
|---|---|---|---|
| Gender (no., % female) | 293 (84.0) | 146 (67.3) | <0.01 |
| Race and ethnicity (no.) | |||
| Asian | 5 | 3 | 0.45 |
| Black | 21 | 7 | |
| Hispanic | 16 | 8 | |
| White | 290 | 192 | |
| Other | 17 | 7 | |
| Region (no.) | |||
| Northeast | 59 | 23 | 0.22 |
| South | 147 | 97 | |
| Midwest | 75 | 49 | |
| West | 68 | 48 | |
| Affluence status | 0.39 ± 0.14 | 0.42 ± 0.15 | <0.02 |
| ASCVD risk factors | |||
| Diabetes mellitus (no., %) | 53 (15.2) | 45 (20.7) | 0.09 |
| Hypertension (no., %) | 210 (60.2) | 168 (77.4) | <0.01 |
| Hypercholesterolemia (no., %) | 201 (57.6) | 180 (83.0) | <0.01 |
| Medications (no., %) | |||
| Diabetes mellitus | 46 (13.2) | 39 (18.0) | 0.12 |
| Hypertension | 167 (47.9) | 140 (64.5) | <0.01 |
| Hypercholesterolemia | 101 (28.9) | 121 (55.8) | <0.01 |
| Smoking status (no., %) | |||
| Current | 38 (10.9) | 11 (5.1) | <0.01 |
| Quit ≤ 1 year | 32 (9.2) | 6 (2.7) | |
| Quit >1 year | 106 (30.4) | 70 (32.3) | |
| Never | 173 (49.5) | 130 (59.9) | |
| Clinical data | |||
| Weight (kg) | 87.9 ± 26.1 | 87.0 ± 23.2 | 0.69 |
| BMI (kg/m2) | 31.4 ± 8.7 | 30.7 ± 8.4 | 0.39 |
| Systolic blood pressure (mmHg)* | 116.5 ± 14.9 | 120.6 ± 13.8 | <0.01 |
| Diastolic blood pressure (mmHg)* | 72.6 ± 10.2 | 74.1 ± 9.4 | 0.08 |
| Total cholesterol (mmol/L)* | 184.6 ± 29.1 | 183.8 ± 40.7 | 0.76 |
| Blood glucose (mmol/L)* | 99.9 ± 20.8 | 106.8 ± 16.3 | <0.01 |
| Diet | |||
| Vegetables/day (cups) | 1.9 ± 1.3 | 1.9 ± 1.2 | 0.70 |
| Fruit/day (cups) | 1.4 ± 1.1 | 1.5 ± 1.2 | 0.20 |
| Fish (servings/week) | 0.9 ± 1.0 | 1.1 ± 1.1 | <0.01 |
| Whole grains (servings/day) | 1.5 ± 1.1 | 1.5 ± 1.1 | 0.90 |
| Sugar-sweetened beverages (servings/week) | 2.7 ± 3.4 | 1.5 ± 2.8 | <0.01 |
| Avoid prepackaged foods (no., %) | 193 (55.3) | 140 (64.5) | <0.04 |
| Avoid eating out (no., %) | 167 (47.9) | 111 (51.2) | 0.45 |
| Avoid salt at home (no., %) | 246 (70.5) | 158 (72.8) | 0.55 |
| Exercise | |||
| Moderate exercise (min/week) | 215.5 ± 236.5 | 194.7 ± 198.7 | 0.28 |
| Vigorous exercise (min/week) | 53.8 ± 107.3 | 60.6 ± 119.8 | 0.48 |
| LS7 Health Score | 6.4 ± 1.5 | 6.0 ± 1.4 | <0.01 |
*Contains imputed data from Life's Simple 7. Categorical variables are analyzed by Chi-Square test. Continuous variables are analyzed by t-test. Non-parametric variables were analyzed by Wilcoxon rank-sum test. CVD, cardiovascular disease; ASCVD, atherosclerotic cardiovascular disease.
Figure 2.
Life's Simple 7 health factors and behaviors in participants with cardiovascular disease aged <50 vs. ≥50 years old. Individuals received a score of poor, intermediate, or ideal for each of the Life's Simple 7 health factor and behaviors categories based on criteria outlined by a panel of experts. Results for young adults (age <50 years) with established cardiovascular disease (n = 349) are compared to those for older adults (age ≥50 years) with cardiovascular disease (n = 217). *p <0.01 by Wilcoxon rank-sum test.
Heterogeneity Among Young Adults With Cardiovascular Disease
We next sought to explore the group of young adults with cardiovascular disease in more detail to determine if there were subgroups of individuals with differences in ideal cardiovascular health habits and behaviors. To identify these subgroups, we performed a latent class analysis. In our population of young adults with prior cardiovascular disease, analysis of latent class models indicated that the best fit was provided by a two-class model with a Vuong-Lo-Mendell-Rubin likelihood ratio test p < 0.03. In this model, the average probability of for class 1 was 0.87 and for class 2 was 0.82 indicating good model fit. This resulted in 173 individuals assigned to phenogroup 1 and 176 individuals assigned to phenogroup 2. Participants assigned to phenogroup 1 were younger (38.2 ± 7.1 vs. 41.4 ± 6.0 yrs, p < 0.01) than participants assigned to phenogroup 2 with no differences in gender, race or ethnicity, or geographic location between the groups. Participants in phenogroup 1 had a substantially lower prevalence of diabetes mellitus (1.7 vs. 28.4%, p < 0.01), hypertension (33.0 vs. 86.9%, p < 0.01), and hypercholesterolemia (45.1 vs. 69.6%, p < 0.01) as well as medication use for these risk factors (all p < 0.01) than participants in phenogroup 2. Phenogroup 1 had lower systolic (110.8 ± 11.4 vs. 122.0 ± 15.8 mmHg, p <0.01) and diastolic (68.5 ± 7.3 vs. 76.6 ± 11.1 mmHg, p < 0.01) blood pressures and fasting blood glucose levels (93.4 ± 7.5 vs. 106.2 ± 26.9 mg/dL, p < 0.01) with similar cholesterol levels as phenogroup 2 individuals. There were no differences between the phenogroups with respect to consumption of a heart healthy diet and following heart healthy dietary habits. Although participants in both phenogroups performed the same amount of weekly moderate exercise (233.1 ± 219.3 vs. 208.0 ± 252.7 min/week, p = 0.55), individuals in phenogroup 1 performed more weekly vigorous exercise (76.4 ± 126.9 vs. 31.5 ± 77.9 min/week, p < 0.01) than those in phenogroup 2. As a result, participants in phenogroup 1 also had significantly higher Life's Simple 7 Health Scores compared to phenogroup 2 (7.4 ± 1.2 vs. 5.5 ± 1.1, p < 0.01).
Digital Health Device Data
A subgroup of young adults contributed weight (n = 210), activity (n = 247), and step count (n = 262) data from digital health devices. Weight measured by digital health devices and the corresponding calculated body mass index remained numerically higher in young adults with cardiovascular disease (n = 77) as compared to individuals without cardiovascular disease (n = 133) (Table 3). When comparing self-reported with digital health device measured weight, on average weight was underreported by both young adults with cardiovascular disease (−0.9 ± 5.7 kg) and without cardiovascular disease (−0.3 ± 3.5 kg). Using digital health device measured weight, differences in the distribution of participants with poor, intermediate, and ideal scores persisted with a greater percentage of young adults with prior cardiovascular disease having poor weight scores (p < 0.05). Using digital health device measured exercise data, participants with prior cardiovascular disease performed a similar number of minutes per week of moderate and vigorous exercise as individuals without cardiovascular disease. When comparing self-reported with digital health device measured activity, young adults with cardiovascular disease on average overreported weekly minutes of moderate exercise (67.5 ± 226.0 min) and underreported weekly minutes of vigorous exercise (−79.3 ± 188.0 min). A similar pattern was seen for young adults without cardiovascular disease who overreported weekly minutes of moderate exercise (85.2 ± 274.6 min) and underreported weekly minutes of vigorous exercise (−34.6 ± 177.2 min). Using digital health device measured exercise data resulted in a similar distribution of participants with intermediate and ideal activity scores between the groups. Participants in both groups also recorded a similar number of daily steps (Table 3), suggesting a similar amount of contact time with their digital health devices.
Table 3.
Digital health device measured weight and exercise data for participants age <50 yrs with or without CVD.
| Age <50 yrs No CVD | Age <50 yrs CVD | P-value | |
|---|---|---|---|
| (n = 133) | (n = 77) | ||
| Weight (kg) | 80.3 ± 20.4 | 82.6 ± 23.9 | 0.45 |
| Delta reported vs. measured weight (kg) | −0.3 ± 3.5 | −0.9 ± 5.7 | 0.35 |
| BMI (kg/m2) | 28.2 ± 6.7 | 29.6 ± 8.1 | 0.17 |
| Delta reported vs. measured BMI (kg/m2) | −0.1 ± 1.3 | −0.4 ± 2.0 | 0.37 |
| Healthy weight score (no., %) | |||
| Poor | 40 (30.1) | 35 (45.4) | <0.05 |
| Intermediate | 42 (31.6) | 19 (24.7) | |
| Ideal | 51 (38.3) | 23 (29.9) | |
| (n = 170) | (n = 77) | ||
| Moderate exercise (min/week) | 127.6 ± 161.3 | 117.7 ± 143.3 | 0.64 |
| Delta reported vs. measured moderate exercise (min/week) | 85.2 ± 274.6 | 67.5 ± 226.0 | 0.62 |
| Vigorous exercise (min/week) | 136.5 ± 176.1 | 137.3 ± 181.6 | 0.97 |
| Delta reported vs. measured vigorous exercise (min/week) | −34.6 ± 177.2 | −79.3 ± 188.0 | 0.07 |
| Physical Activity Score (no., %) | |||
| Poor | 0 (0.0) | 0 (0.0) | 0.82 |
| Intermediate | 68 (40.0) | 32 (41.6) | |
| Ideal | 102 (60.0) | 45 (58.4) | |
| (n = 123) | (n = 72) | ||
| Recalculated LS7 Health Score | 7.4 ± 1.2 | 6.9 ± 1.3 | <0.03 |
| (n = 179) | (n = 83) | ||
| Steps per day | 7,402.4 ± 4,553.2 | 7,537.7 ± 3,960.4 | 0.82 |
Categorical variables are analyzed by Chi-Square test. Continuous variables are analyzed by t-test. Non-parametric variables were analyzed by Wilcoxon rank-sum test.
Discussion
In this analysis of ideal cardiovascular health in young adults with cardiovascular disease, we found such individuals were less likely to achieve ideal scores in 5 or more Life's Simple 7 cardiovascular health and behavior categories and had lower Health Scores compared to young adults without cardiovascular disease. We identified similarities in ideal cardiovascular health categories between young and older adults with cardiovascular disease, including similar body mass index, dietary habits, and exercise patterns. In a subset of young adults, we also examined the effect of substituting digital health device data for self-reported data to assess ideal cardiovascular health. Here, we found that substituting digital health device activity data for self-reported data resulted in improvements in the activity category score for young adults with cardiovascular disease. When comparing self-reported and digital health device measured weight and exercise activity data, we noted that individuals tended to underreport their weight and weekly minutes of vigorous activity while overreporting their weekly minutes of moderate activity. The observed difference between self-reported and measured data is in line with what was observed in the entire My Research Legacy study sample (21).
We also explored heterogeneity among young adults enrolled in the study using latent class analysis and found that there were two phenogroups. These phenogroups were significantly different for 6 of the 7 ideal cardiovascular health and behavior categories. Compared to phenogroup 1, young adults with cardiovascular disease assigned to phenogroup 2 had a significantly higher body mass index, prevalence of cardiovascular disease risk factors, and performed fewer minutes of weekly vigorous exercise, which is consistent with their lower overall Health Scores. The ramifications of a lower Health Score have been determined in a longitudinal study that reported that each one-point increase in the Health Score was associated with a 12% decreased risk of major adverse cardiovascular events when the Life's Simple 7 Health Score was calculated on a 0–14-point scale (31). The heterogeneity identified between these phenogroups also highlights the substantial differences in the health factors and behaviors that comprise ideal cardiovascular health among young adults with established disease. This finding suggests that members of phenogroup 1 may have made optimized their cardiovascular health factors and behaviors following their event or they may have had an event despite having ideal cardiovascular health. This latter explanation is plausible as the event may be attributable to mechanisms other than typical atherosclerotic cardiovascular disease associated with cardiovascular events in older individuals, such as plaque erosion, microvascular disease, vasospasm, or spontaneous coronary artery dissection (32). In contrast, members of phenogroup 2 with less-than-ideal cardiovascular health represent a group of young adults that has yet to optimize their cardiovascular health factors and behaviors and may be at higher risk for recurrent events. This hypothesis is supported by studies that have demonstrated increased risk of cardiovascular events in young adults with hypertension (33), hypercholesterolemia (34), diabetes mellitus (35), obesity (36), combustible tobacco use (37), unhealthy diet (38), and sedentary behavior (39, 40).
The importance of assessing ideal cardiovascular health in young adults is necessary as ideal levels of cardiovascular health factors and behaviors decline with age. In NHANES, the prevalence of young adults aged 20–39 years with ideal blood pressure, blood glucose, total cholesterol, weight, and diet who abstain from use of combustible tobacco was lower than in teenagers aged 12–19 years. Although the percentage of young adults with ideal physical activity was higher compared to teenagers, it was also higher than in adults aged 40–59 years, suggesting that ideal physical activity also declines with aging (1).
Assessing modifiable cardiovascular health factors and habits in young adults also has important ramifications for cardiovascular risk prediction. This was demonstrated in a study of 36,030 individuals enrolled in 6 community-based cohort studies. When exposures as a young adult were considered, elevated levels of low-density lipoprotein cholesterol and diastolic blood pressure were associated with a 64% increased risk of coronary heart disease while elevated systolic blood pressure was associated with a 37% increased risk of heart failure (41). Similarly, physical inactivity assessed as cumulative sedentary behaviors was also associated with an increased risk of cardiovascular disease (pooled relative risk, 2.47; 95% CI, 1.44–4.24) (42, 43). Exploratory studies have also linked physical inactivity to a decrease in insulin sensitivity and diminished conduit and resistance artery compliance compared to what was observed in physically active young adults (44).
Ideal cardiovascular health in young adults is affected by several factors, including awareness, behaviors, as well as socioeconomic status. Socioeconomic status has been shown to influence cardiovascular risk factors and this relationship holds regardless of the socioeconomic risk indicator (e.g., income, occupation, education) studied or if analyzed at the individual, family, or neighborhood level (45). Our study found that young adults with cardiovascular disease had a lower affluence index than those without, which is consistent with prior reports. Ideal cardiovascular health may also be related to awareness of cardiovascular risk factors, which was analyzed in 11,083 young adults aged 18–39 years in the United States. Awareness of hypercholesterolemia, hypertension, and diabetes mellitus exceeded 60%; however, awareness of borderline increased levels of blood glucose, cholesterol, and blood pressure was significantly lower (5.7, 22.5, and 12.3%, respectively). Levels of awareness were affected by race and ethnicity, educational level, and socioeconomic status with lower levels reported in Blacks and Hispanics as well as individuals with lower socioeconomic status (46).
In our study, the definition of cardiovascular disease included myocardial infarction, stroke, cardiomyopathy/systolic heart failure, atrial fibrillation, and aortic dissection in order to capture a broad representation of cardiovascular diseases in young adults. To date, there are few studies that have focused solely on cardiovascular health and disease in young adults, and none explored ideal cardiovascular health in young adults with established cardiovascular diseases. Two large community-based studies, the Coronary Artery Risk Development in Young Adults (CARDIA) study and the Young Finns Study, examined the relationship between risk factors and incident atherosclerotic cardiovascular disease or subclinical atherosclerosis, respectively (20). The CARDIA study enrolled 5,115 young adults aged 18–30 years and confirmed that traditional risk factors assessed in the Life's Simple 7 survey, including age, sex, hypertension, diabetes mellitus, and hypercholesterolemia, correlated with coronary calcium levels (47). The Young Finns Study, which enrolled 3,596 individuals aged 3–18, reported that obesity, tobacco use, hypertension, and hyperlipidemia predicted subclinical atherosclerosis in young adults (48). Additional analyses also associated diet and physical activity, both assessed as part of the Life's Simple 7 survey, with subclinical atherosclerosis (49). In contrast to our study, young adults with cardiovascular disease were not enrolled and ideal cardiovascular health wasn't assessed.
Several large community-based studies that included young adults analyzed the relationship between ideal cardiovascular health (assessed by the Life's Simple 7 survey tool) and incident cardiovascular diseases. The Framingham Heart Study, the Multi-Ethnic Study of Atherosclerosis (MESA), and the Atherosclerosis Risk in Communities (ARIC) studies have all reported that ideal cardiovascular health was associated with a lower risk of incident atherosclerotic cardiovascular disease (16, 50–52), heart failure (15, 53), and atrial fibrillation (54). However, none of these studies examined ideal cardiovascular health specifically in young adults or in young adults with established cardiovascular disease. Therefore, our study design, which included participants with and without established cardiovascular disease, has implications for future studies that examine ideal cardiovascular health in real world samples of young adults. These studies should include individuals with established cardiovascular disease and the definition of cardiovascular diseases should be sufficiently broad to ensure representation of typical cardiovascular diseases prevalent in young adults. Future studies should also be broadly inclusive in order to examine the role of gender, race, and ethnicity, as well as social determinants of health on ideal cardiovascular health in young adults.
Our study was enriched for young women with cardiovascular disease (female to male ratio of 4.6:1), which is not surprising as recent analyses from community-based studies have identified an increase in cardiovascular disease in young women. An analysis from ARIC of 20-year trends for myocardial infarction in young adults (age 35–54 years) reported that the largest increase in the annual incidence of hospitalization for myocardial infarction was seen in young women. Compared to young men with myocardial infarction, young women had a higher burden of comorbidities, were more often Black, and were less likely to be treated with guideline-directed medical or invasive therapies (3). A similar phenomenon has also been observed for young women with stroke. A retrospective analysis of an insurance claims database in the United States demonstrated that the incidence rate ratio of men to women was 0.70 (95% CI, 0.57–0.86) for individuals aged 25–34 years and 0.87 (95% CI, 0.78–0.98), for individuals aged 35–44 years, indicating that more young women than young men had strokes (55). Similarly, the European 15 Cities Young Stroke Study reported that there were 30% more strokes in young women than young men (56).
Our study has several limitations that have the potential to affect the generalizability of our findings. First, our study enrolled a relatively small sample size compared to larger community-based studies, such as NHANES. We also considered several cardiovascular diseases, including myocardial infarction, stroke, atrial fibrillation, systolic heart failure/cardiomyopathy, and aortic dissection, as a composite of prevalent cardiovascular diseases in young adults (20). Since our study design was direct-to-participant, we relied on participant responses to disease-specific questions written by a panel of experts to establish the diagnosis of cardiovascular disease and were not able to review electronic health or other medical records. Several studies assessed the accuracy of self-reported cardiovascular diseases and reported that the positive predictive value for myocardial infarction ranged from 39 to 84%, and 33 to 81% for stroke. These studies, however, were conducted in older patient populations and it is likely that there are notable differences between the participants enrolled in these studies and our young adult population (57, 58). Our study did not collect a family history of cardiovascular disease and it is not assessed as part of the Life's Simple 7 survey. Family history, which is considered an indicator of shared genetic and environmental exposures, is a well-recognized risk factor for cardiovascular diseases (59). A family history of cardiovascular disease as well as a family history of premature cardiovascular disease have been shown to associate independently with coronary heart disease risk and incident atherosclerotic cardiovascular disease and, therefore, are important determinants of additional risk information for asymptomatic individuals (60). By study design, we examined digital health device data in only a subset of participants and, therefore, were underpowered to analyze the effect of substituting digital health data for self-reported data for individual cardiovascular diseases. Finally, we do not have longitudinal outcome data to determine if there are shifts between the phenogroups of young adults with cardiovascular disease over time.
In summary, our study demonstrated that young adults with established cardiovascular diseases have less ideal cardiovascular health factors and habits than young adults without disease and more closely resemble older adults with cardiovascular disease. Our sample of young adults with cardiovascular disease was heterogeneous and comprised of two phenogroups with different cardiovascular risk profiles indicating that ideal cardiovascular health in young adults with established disease is complex. The relationship between these phenogroups and clinical outcomes warrants investigation in future studies as our findings may have implications for designing behavioral and therapeutic interventions in the future to improve cardiovascular morbidity and mortality.
Data Availability Statement
The data are not publicly available due to privacy restrictions and protection of personal data. Requests to access the datasets should be directed to Jane Leopold, jleopold@bwh.harvard.edu.
Ethics Statement
The studies involving human participants were reviewed and approved by Advarra Institutional Review Board. The patients/participants provided their written informed consent to participate in this study.
Author Contributions
JL and EA: conceptualization, investigation, writing—original draft preparation, and writing—review and editing. JL: formal analysis and data curation. Both authors have read and agreed to the published version of the manuscript.
Funding
This research was funded by the American Heart Association AIM 19AIML34980000, the National Institutes of Health, and National Heart, Lung, and Blood Institute U01 HL125215 (JL).
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary Material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fcvm.2022.814610/full#supplementary-material
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Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Supplementary Materials
Data Availability Statement
The data are not publicly available due to privacy restrictions and protection of personal data. Requests to access the datasets should be directed to Jane Leopold, jleopold@bwh.harvard.edu.