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. 2022 Feb 17;13:832529. doi: 10.3389/fphar.2022.832529

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Copyright © 2022 Servant, Williams, Brust, Tang, Wong, Chen, Lebl-Rinnova, Adamski-Werner, Tachdjian and Servant.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dose-response analysis of sweet taste receptor agonists in the DMR and FLIPR assays. Agonists were evaluated in the DMR assay with R2/R3 U2OS cells (A) and U2OS parental cells (B) and in the FLIPR assay with R2/R3 U2OS cells transduced with a Bacmam virus encoding Gα₁₅ (C) as described in Materials and Methods. (D) Kinetics of indicated agonist responses in the DMR assay using R2/R3 U2OS cells. Dose-responses are representative of several independent experiments and each data point corresponds to an average and standard deviation of a triplicate determination.