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. 2022 Feb 17;13:832529. doi: 10.3389/fphar.2022.832529

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Copyright © 2022 Servant, Williams, Brust, Tang, Wong, Chen, Lebl-Rinnova, Adamski-Werner, Tachdjian and Servant.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potency and efficacy bias analysis. (A) Agonist potency values (pEC50s) obtained in each assay were normalized to that of sucralose as described in Materials and Methods. Each pair of the resulting values (pEC50R(sucralose)) were then analyzed by an unpaired, t-test (α = .05). (B) Agonist efficacy (Emax) values obtained in each assay were and summarized in Table 1 were plotted against each other. Each pair of Emax values were analyzed by an unpaired, t-test (α = .05) (***p < 0.001, **p < .01, *p < .05).