TABLE 1.
Summary of potency and efficacy values for sweet taste receptor agonists used in this study. Agonist Emax values were compared to that of sucralose in the same assay and analyzed by an unpaired, two-tailed t-test (α = .05).
| Sweetener | Activity in DMR assay | Activity in FLIPR assay | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EC50 (μM) | pEC50 | SD | N | Emax | SD | N | EC50 (μM) | pEC50 | SD | N | Emax | SD | N | |
| S819 | 0.7 | 6.196 | 0.114 | 4 | 143* | 9 | 4 | 0.07 | 7.128 | 0.041 | 3 | 181**** | 6 | 3 |
| S679 | 1.3 | 5.914 | 0.147 | 7 | 133 | 12 | 3 | 0.7 | 6.145 | 0.115 | 4 | 159**** | 20 | 4 |
| S1313 | 1.5 | 5.822 | 0.120 | 7 | 130 | 8 | 3 | 0.7 | 6.177 | 0.159 | 4 | 170**** | 22 | 4 |
| S5227 | 2.2 | 5.685 | 0.184 | 4 | 128 | 9 | 4 | 0.3 | 6.475 | 0.059 | 3 | 177**** | 8 | 3 |
| P-4000 | 3.8 | 5.423 | 0.097 | 7 | 102 | 7 | 3 | 2.2 | 5.674 | 0.144 | 3 | 164**** | 20 | 3 |
| SC-45647 | 4.3 | 5.388 | 0.146 | 10 | 97** | 18 | 6 | 2.3 | 5.642 | 0.095 | 4 | 98** | 4 | 4 |
| Neotame | 7.7 | 5.137 | 0.156 | 4 | 99* | 7 | 4 | 1.6 | 5.815 | 0.077 | 4 | 116**** | 6 | 4 |
| Superaspartame | 9.8 | 5.023 | 0.128 | 4 | 109 | 8 | 4 | 4.7 | 5.335 | 0.053 | 4 | 105 | 1 | 4 |
| Dulcin | 33 | 4.513 | 0.166 | 9 | 57**** | 7 | 9 | 23 | 4.637 | 0.061 | 4 | 87**** | 5 | 4 |
| Alitame | 37 | 4.488 | 0.231 | 4 | 106 | 27 | 4 | 20 | 4.713 | 0.054 | 4 | 100 | 4 | 4 |
| rebaudioside A | 57 | 4.293 | 0.238 | 7 | 103 | 26 | 3 | 29 | 4.538 | 0.066 | 4 | 106 | 6 | 4 |
| Stevioside | 127 | 3.943 | 0.212 | 7 | 141 | 60 | 3 | 51 | 4.300 | 0.079 | 4 | 102 | 5 | 4 |
| Sucralose | 163 | 3.825 | 0.174 | 22 | 122 | 19 | 22 | 72 | 4.159 | 0.115 | 22 | 104 | 4 | 22 |
| Saccharin | 411 | 3.482 | 0.402 | 6 | 145 | 47 | 3 | 241 | 3.743 | 0.351 | 4 | 90**** | 5 | 4 |
| Aspartame | 910 | 3.113 | 0.246 | 6 | 143 | 17 | 3 | 354 | 3.453 | 0.043 | 4 | 106 | 6 | 4 |
| acesulfame K | 1,221 | 3.043 | 0.352 | 6 | 122 | 78 | 3 | 253 | 3.601 | 0.069 | 4 | 73**** | 7 | 4 |
****p < .0001, **p < .01, *p < .05.