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. 2022 Feb 17;10:841017. doi: 10.3389/fcell.2022.841017

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Copyright © 2022 Dietrichs, Grimm, Sahana, Melnik, Corydon, Wehland, Krüger, Vermeesen, Baselet, Baatout, Hybel, Kahlert, Schulz, Infanger and Kopp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extracellular matrix: Gene expression of (A) FN1 and immunofluorescence of fibronectin: left two images of the 1g/24 h sample (merged left picture and fibronectin (Alexa Fluor 488) right picture), top right two images of the RPM/24 h MCS samples (merged left picture and fibronectin right picture) and lower right two images of the RPM/24 h AD samples (merged left picture and fibronectin right picture), DAPI-stained nucleus (blue), (B) COL1A1, (C) LAMA3, (D) SPP1, (E) MMP9, and (F) TIMP1 of PC-3 cells exposed to the RPM for 30 min, 2, 4 and 24 h and 1g-MCS after 24 h. n = 5; *p < 0.05 vs. 1g.