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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Free Radic Biol Med. 2021 Nov 12;179:363–374. doi: 10.1016/j.freeradbiomed.2021.11.015

Table 1:

Protein interactions with mtHsp70 under recent investigation

Protein Subcellular location Function Reference
IP3R - VDAC1 complex Mitochondria Associated Membrane Calcium transport from endoplasmic reticulum to mitochondria [119]
HEP1 Matrix side of Inner mitochondrial membrane Co-chaperone, stimulates Hsp70 ATPase activity [120]
GRPEL1/2 Mitochondrial matrix, Co-chaperone, nucleotide exchange factor for Hsp70 [120]
TID-1 Mitochondrial matrix (TID-1S), cytosol (TID-1L) Co-chaperone, stimulates Hsp70 ATPase activity [120]
PERK / IRE1/ ATF6 ER lumen Unfolded protein response [121]
Lon protease Mitochondrial matrix Inhibits apoptosis by stabilizing mtHsp60, stabilizes Hsp70-Hsp60 complex. [122]
TLR2 Plasma membrane Extracellular Hsp70 and mtHsp60 recognized as DAMP and trigger pro-inflammatory cascade. [123]