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. 2022 Feb 14;18(2):e1010327. doi: 10.1371/journal.ppat.1010327

Fig 2. Body weights, organ weights and histopathological profile of chronic S. mansoni infected mice post Inactivated Poliovirus Vaccine (IPV) immunisation and after treatment with PZQ.

Fig 2

(A) Body weight changes over time. Note a drastic weight drop in the Vac+ Sm+ group that is rescued in the Vac+Sm+PZQ+ group. (B) Spleen/body weight index at week 18 p.i (C) Liver/body weight index at week 18 p.i (D) Number of eggs per gram of liver or gut at 18 week p.i (E) Serum anti-polio IgG titre kinetics response to poliovirus vaccination in schistosomiasis-infected mice for all mice at week 4, 8 and 18 p.i (F) Anti-poliovirus IgG titres at week 18 p.i Data are expressed as mean ± S.E.M and representative of 2 independent experiments (n = 4–10 mice per group in each experiment); Data was analysed by Shapiro-Wilk test. Data was analysed by one way ANOVA followed by the Bonferroni’s multiple comparisons test (B-C); two tailed Student’s t test for unequal variances (D); two-way ANOVA followed by FDR corrected multiple comparisons with Vac+ group as a statistical reference with (E-F) and colour codes of black (comparison Vac+ vs Naive), red (comparison vac+ vs vac+Sm+), blue (comparison vac+ vs vac+sm+PZQ+) and green (vac+Sm+ vs Vac+Sm+PZQ+); ns, p> 0.05; * p< 0.05, ** p< 0.001, *** p< 0.0001; Vac, hexavalent (DTPa-hepB-IPV-Hib) vaccine; Vac+, vaccinated; Sm, S mansoni; Sm+, infected with S. mansoni; PZQ, praziquantel; PZQ+, treated with PZQ;p.i, post S. mansoni infection.