Skip to main content
. 2022 Feb 14;18(2):e1010327. doi: 10.1371/journal.ppat.1010327

Fig 5. Schistosomiasis-driven death of plasma cells and plasmablasts in the bone marrow is not mediated by apoptosis.

Fig 5

(A) Representative gating strategy, illustrative, of apoptotic cells (Annexin V+ Zombie Red-), necrotic cells (Annexin V+ Zombie Red+) and live cells (Annexin V- Zombie Red-) that were each sub-gated for frequencies of plasma blasts or plasma cells at week 18 post-infection. Frequencies of plasma cells (CD138+B220-) within the liver (B.), dead (C.) and apoptotic (D.) IgD-IgG1- B cells of the bone marrows. Frequencies of plasmablasts (CD138+B220+) within the live (E.), dead (F.) and apoptotic (G.) IgD-IgG1- B cells of the bone marrows. Data are expressed as mean ± S.E.M and representative of 2 independent experiments (n = 6–10 mice per group in each experiment); The Vac+ group is used throughout as reference for statistical comparison. Data was analysed by two-way ANOVA followed by FDR corrected multiple comparisons against the Vac+Sm+ group; ns, p> 0.05; * p< 0.05, ** p< 0.001, *** p< 0.0001; PZQ, praziquantel.