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A) Simulation snapshots. B) Electron density plot for R44Y/S60Y St_βIB1 and the POPC bilayer for two replica (solid lines and dashed lines). C) Bound protein orientation. D) Depth of anchorage. The depth is calculated for each amino acid as the distance between its C-alpha and the phosphate plane in the last frame of simulation (relevant values are given in Table A in S2 Text).
