Table 3. Adjusted hazard ratio for overall survival in each treatment.

	Best supportive care			Doublet chemotherapy			Metastasectomy			Doublet chemotherapy or Metastasectomy
	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value
Differentiation
Wel/Mod	(reference)			(reference)			(reference)			(reference)
Por/Muc/Sig	1.02	(0.66–1.60)	0.91	1.48	(1.05–2.07)	0.023	2.25	(0.92–5.54)	0.077	1.51	(1.10–2.06)	0.011

Adjusted for age, sex, CCI, primary tumor site, T-factor, N-factor, liver metastasis, lung metastasis, peritoneal dissemination, distal lymph node metastasis, other-organ metastasis, and the number of organs with metastasis.

Abbreviations: HR = hazard ratio.