Table 2. Peaks at genes belonging to CovR regulon.
| M5005 Spy# | MGAS2221 # | Gene | location | CovR binding in MGAS2221 | CovR binding in 2221-CovS-E281A | RPKL ratio MGAS2221/2221-CovS-E281A | Transcript level ratio: 2221-CovS-E281A/MGAS2221 |
|---|---|---|---|---|---|---|---|
| Virulence factor encoding genes | |||||||
| _0139 | _0183 | nga | promoter* | + | - | 7.49 | 4.98 |
| _1687 | _0251 | sclA | promoter | + | + | 4.73 | 38.63 |
| _1684 | _0254 | ska | promoter | + | + | 2.65 | 1.53 |
| _0281 | _0340 | dahA | promoter | + | - | 2.69 | 1.78 |
| _0341 | _0397 | prtS | promoter | + | + | 3.57 | 23.81 |
| _0351/2 | _0403/4 | spyA/hypo | promoter | + | - | 6.63 | 4.51 |
| _0356 | _0408 | speJ | promoter | + | - | 5.39 | 3.80 |
| _0562 | _0598 | sagA | promoter | + | + | 1.11 | 0.69 |
| _0570 | _0606 | sagI | intergenic | + | - | 3.67 | 0.69 |
| _0668 | _0700 | mac-1 | promoter | + | + | 2.59 | 13.80 |
| _0777 | _0802 | sclB | promoter | + | + | 3.44 | 1.83 |
| _0981 | _0993 | cfa | promoter | + | + | 1.23 | 0.31 |
| _0996 | _1009 | speA2 | promoter | + | - | 3.14 | 7.66 |
| _1106 | _1119 | grab | promoter | + | + | 1.10 | 0.09 |
| _1169 | _1179 | spd3 | promoter | + | - | 3.80 | 0.86 |
| _1407 | _1422 | esterase | promoter | + | - | 2.49 | 7.45 |
| _1415 | _1430 | sda1 | promoter | + | + | 2.17 | 2.54 |
| _1715 | _1697 | scpA | promoter | + | - | 8.33 | 2.06 |
| _1718 | _1699 | sic | promoter | + | - | 8.54 | 2.36 |
| _0668 | _1700 | emm | intragenic | - | + | 0.36 | 1.14 |
| _1851 | _1825 | hasA | promoter | + | + | 6.33 | 17.83 |
| Transcriptional regulators | |||||||
| _0034 | _0066 | rgg4/comX | promoter | + | + | 1.44 | 1.92 |
| _0282 | _0341 | covR | promoter | + | + | 0.69 | 0.99 |
| _1307 | _1314 | trxTRS | promoter | + | + | 0.48 | 0.64 |
| _1578/9 | _1588/9 | XRE family protein | promoter | + | - | 4.01 | 1.09/1.51 |
| _0195 | _1690 | MarR family | promoter | - | + | 0.61 | 0.32 |
| _0670 | _1701 | mga | promoter | + | + | 2.77 | 1.07 |
| Transport and metabolism | |||||||
| _0146 | _0189 | metB | promoter | + | - | 4.09 | 0.12 |
| _1708 | _0232 | dppE | intragenic | + | + | 1.77 | 1.44 |
| _1704 | _0236 | dppA | promoter | + | + | 0.97 | 1.42 |
| _0274 | _0333 | braB | promoter | + | + | 0.88 | 0.59 |
| _0473/4 | _0516/7 | msf/licT | promoter | + | + | 0.59 | 0.35 |
| _1601 | _1610 | hflc | promoter | + | - | 7.77 | 1.30 |
| _0249/8 | _1638/9 | oppA/dacA | promoter | + | + | 2.02 | 1.10/1.52 |
| _1850 | _1824 | zinc protease | intragenic | + | + | 3.94 | 1.37 |
| Synthesis, DNA repair | |||||||
| _1291 | _1299 | cas3 | promoter | + | - | 4.09 | 4.15 |
| _1556/7 | _1567/8 | hypo/mutY | promoter | + | - | 4.15 | 3.38/1.73 |
| Unknown function/hypothetical genes | |||||||
| _0115 | _0159 | hypo | promoter | + | + | 2.46 | 14.15 |
| _0142 | _0186 | hypo | promoter | + | - | 5.67 | 5.86 |
| _0143 | _0187 | hypo | promoter | + | + | 2.99 | 2.64 |
| _0144 | _0188 | hypo | promoter | + | + | 3.17 | 6.51 |
| _0354 | _0406 | hypo | promoter | + | + | 3.83 | 4.68 |
| _0355 | _0407 | hypo | promoter | + | + | 3.09 | 11.41 |
| _1209 | _1218 | hypo | promoter | - | + | 0.56 | 0.41 |
| _1731 | _1711 | grm/hypo | promoter | + | - | 4.92 | 1.84 |