Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 3;28(6):882.e1–882.e7. doi: 10.1016/j.cmi.2022.02.030

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Fig. 1 — Neutralization of wild-type Wuhan strain and variants of concern (VOCs) Alpha, Beta, and Delta by vaccine sera. (a) Percentages of vaccines that have seroprotective neutralization titres (neutralizer, IC₅₀ >16) and non-neutralizers (IC₅₀ < 16) are indicated in light blue and coral, respectively. Neutralization titres of sera against the indicated Wuhan strain and VOCs are expressed as IC₅₀ values. The numbers indicate the percentage of neutralizers. (b) Percentages of vaccinated individuals who have no detectable serum neutralizing titres (IC₅₀ < 4) and seroconservative titres (IC₅₀ > 4) against the indicated wild-type Wuhan strain and VOCs. Individuals with an IC₅₀ of neutralization above 4 were considered neutralizers and are showed in teal. Non-neutralizers are in grey. (c) IC₅₀ titres of sera from vaccinated individuals (n = 32) against Wuhan strain and Alpha, Beta, and Delta variants. Each dot represents the IC₅₀ for a single donor. The black lines show geometric mean titres (GMTs). The threshold for neutralizing activity was set at an IC₅₀ of 16 (dashed line). A two-sided Friedman test with Dunn's multiple comparison was conducted between each of the SARS-CoV-2 strains. (d) Neutralizing titre of sera from vaccinees, sampled at week 4 (n = 13) and week 6 after vaccination (n = 19) with CovIran. A multiple Mann-Whitney test was performed between samples from week 4 and week 6 after vaccination; p values were not significant. (e) Correlation of participant age with serum neutralizing antibody titre against the Wuhan strain and VOCs. (f) Comparison of neutralizing antibody activity against the Wuhan strain and VOCs between two age groups (individuals >50 years and <50 years of age). Analysis for comparison of neutralizing activity of age groups was performed via Mann-Whitney test. (g–i) Correlation of neutralizing capacity against Alpha (g), Beta (h), and Delta (i) variants with that of wild-type Wuhan strain. Spearman r was used to determine correlations. Values from statistical analysis are depicted in the grey box.