. 2021 Dec 2;71(3):381–393. doi: 10.2337/db21-0609

Table 3.

Relationship between IC₅₀ and AT inflammatory markers

	Study 1 (N = 48)				Study 2 (N = 38)
	IC₅₀ r	P	Adjusted P^*	P ^†	IC₅₀ r	P	Adjusted P^*	P ^†
Inflammatory markers
Macrophages in abdominal fat depot (ATM per 100 adipocytes)
CD68	0.33	0.02	0.87	0.91	0.36	0.06	0.68	0.13
CD14	0.30	0.04	0.46	0.48	0.50	0.007	0.24	0.16
CD206	0.51	<0.001	0.34	0.36	0.50	0.007	0.24	0.18
Macrophages in abdominal fat depot (ATM per milligrams of tissue)
CD68	−0.21	0.17	0.77	0.79	−0.15	0.42	0.57	0.13
CD14	−0.02	0.88	0.29	0.29	0.15	0.53	0.27	0.24
CD206	−0.26	0.08	0.95	0.97	−0.03	0.84	0.25	0.32
Macrophages in femoral fat depot (ATM per 100 adipocytes)
CD68	0.29	0.07	0.68	0.49
CD14	0.17	0.29	0.73	0.73
CD206	0.37	0.02	0.17	0.19
Macrophages in femoral fat depot (ATM per milligrams of tissue)
CD68	−0.20	0.22	0.94	0.87
CD14	−0.11	0.38	0.54	0.54
CD206	−0.19	0.25	0.40	0.43
Cytokines in abdominal fat depot
IL-6	0.37	0.04	0.34	0.38
TNF-α	0.44	0.01	0.38	0.37
IL-1β	0.40	0.02	0.72	0.61
IL-10	0.43	0.01	0.12	0.13
Cytokines in femoral fat depot
IL-6	−0.12	0.50	0.47	0.49
TNF-α	0.45	0.007	0.002	0.002
IL-1β	0.26	0.14	0.02	0.02
IL-10	0.33	0.05	0.07	0.07
SA-β-gal staining cells (%)
Abdominal depot	0.36	0.03	0.45	0.37	0.29	0.28	0.68	0.37
Femoral depot	0.36	0.03	0.10	0.04

Analysis adjusted for FCS.

^†

Analysis adjusted for FCS and sex with multiple linear regression. P value <0.05 was considered statistically significant for the predefined primary end points: association between IC₅₀ and FCS, association between IC₅₀ and total (CD68) and proinflammatory (CD14) ATM content, the association between IC₅₀ and senescent cell content, and association between IC₅₀ and inflammatory cytokine gene expression (IL-6 and TNF-α). P value <0.01 was considered statistically significant for the association between IC₅₀ and anti-inflammatory (CD206) ATM content, between IC₅₀ and IL-1β, and between IC₅₀ and IL-10.