TABLE 2.
The cps mutations in Nm carriage isolates with discrepant capsule typing results.
| Serogroup by SASG (No.) | WGS analysis | No. (%) |
| B (23) | Internal stop in csb | 1 (4.3%) |
| Internal stop in cssA | 1 (4.3%) | |
| Internal stop in cssA, phase variable offa in csb | 1 (4.3%) | |
| Internal stop in ctrE | 1 (4.3%) | |
| Phase variable off in csb | 19 (82.6%) | |
| E (24) | cseD disrupted by IS1301 | 3 (12.5%) |
| Internal stop in cseA | 6 (25%) | |
| Internal stop in cseD | 10 (41.7%) | |
| Missing cseA, missing cseB, missing cseC, missing cseD | 1 (4.1%) | |
| cseG fragmented (31.89% coverage), ctrA fragmented (20.98% coverage), internal stop in cseG, missing cseA, missing cseB, missing cseC, missing cseD, missing cseE | 1 (4.1%) | |
| Internal stop in cseC, internal stop in ctrA | 1 (4.1%) | |
| Internal stop in cseD, internal stop in cseG | 2 (8.3%) | |
| Y (2) | Internal stop in cssA | 1 (50%) |
| cssC disrupted by IS1655 | 1 (50%) |
Nm, Neisseria meningitidis; No., number of isolates; SASG, slide agglutination serogrouping; WGS, whole genome sequencing.
aDefined as frameshifts arising from length variation in mononucleotide repeats.