Fig. 1.
Scavenger receptors implicated in liver homeostasis and pathogenesis, including receptor class, shared structural domains, liver cell expression, and functional role within the liver. Functions shown in green are considered protective and those shown in red are considered detrimental. Context-dependent functions are indicated in black . Figure created using biorender.com. ALF, acute liver failure; DC, dendritic cells; EC, endothelial cell; EGF, epidermal growth factor; HCC hepatocellular carcinoma; HCV, hepatitis C virus; HDL, high-density lipoprotein; HSC, hepatic stellate cell; LAMP, lysosome-associated membrane glycoprotein; LSEC, liver sinusoidal endothelial cell; Mϕ, macrophage; M Ø , monocyte; NK, natural killer cell; NKT, natural killer T cell; oxLDL, oxidized low-density lipoprotein; PRR, pattern recognition receptor; SR, scavenger receptor; TAM, tumor-associated macrophage; TEM, transendothelial migration; T eff , T effector cell; T reg , regulatory T cell.