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. 2021 Sep 22;42(1):61–76. doi: 10.1055/s-0041-1733876

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Scavenger receptors represent valid therapeutic targets and are often valuable for use as biomarkers of liver disease, either in their soluble form in the serum or their cellular form within the tissues. This table summarizes the translational stage of each scavenger receptor, including in vitro and in vivo preclinical models and ongoing or completed clinical trials. Figure created using biorender.com. ALF, acute liver failure; ALI, acute liver injury; CEA, carcinoembryonic antigen; FA, fatty acid; Hb-Hp, hemoglobin–haptoglobin complex; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; hLSEC, human liver sinusoidal endothelial cells; hMDMs, human monocyte-derived macrophages; HSC, hepatic stellate cells; mBMDMs, murine bone marrow-derived macrophages; mLSEC, murine liver sinusoidal endothelial cells; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; NS3, nonstructural 3 protein; oxLDL, oxidized low-density lipoprotein; TAM, tumor-associated macrophage; T _reg , regulatory T cells; TWEAK, tumor necrosis factor-like weak inducer of apoptosis.