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The selected cases of brain-targeting prodrugs transported via endogenous transporters at the BBB. (a) Ibuprofen prodrug transported via GLUT1 and SVCT2; (b) naproxen prodrug transported via GLUT1 and SVCT2; (c) ketoprofen prodrug transported via LAT1; and (d) nipecotic acid transported via OCTN2. GLUT1: glucose transporter 1; SVCT2: sodium-vitamin C transporter 2; LAT1: large neutral amino acid transporter 1; OCTN2: organic cation/carnitine transporter 2.
