Table 7.
Results of sulfadiazine concentrations (μg/gm) in different boiler tissues after administration of 33.34 mg/kg b.wt. for 5 days.
Tissue | Groups | 1st day | 2nd day | 3rd day | 4th day | 5th day | MRL |
---|---|---|---|---|---|---|---|
Muscle | Antibiotic in normal healthy group | 110 ± 9 | 47.3 ± 3.1 | ND | ND | ND | 100 |
Antibiotic + MDR infected group | 86 ± 6∗ | 31 ± 3∗ | ND | ND | ND | ||
Antibiotic + SS infected group | 88 ± 6∗ | 33 ± 3∗ | ND | ND | ND | ||
Antibiotic + MDR infected group fed on thyme microemulsion | 84 ± 5∗ | 29 ± 2∗ | ND | ND | ND | ||
Antibiotic + SS infected group fed on thyme microemulsion | 83 ± 6∗ | 27 ± 2∗ | ND | ND | ND | ||
Liver | Antibiotic in normal healthy group | 196 ± 8 | 119 ± 10 | 86 ± 7 | 63 ± 10 | 36 ± 5 | |
Antibiotic + MDR infected group | 142 ± 11∗ | 99 ± 7∗ | 72 ± 4∗ | 45 ± 4∗ | ND | ||
Antibiotic + SS infected group | 144 ± 10∗ | 100 ± 8∗ | 72 ± 3∗ | 47 ± 3∗ | ND | ||
Antibiotic + MDR infected group fed on thyme microemulsion | 139 ± 11∗ | 97 ± 6∗ | 67 ± 2∗ | 43 ± 4∗ | ND | ||
Antibiotic + SS infected group fed on thyme oil microemulsion | 134 ± 9∗ | 94 ± 6∗ | 66 ± 3∗ | 40 ± 2∗ | ND | ||
Kidney | Antibiotic in normal healthy group | 515 ± 53 | 342 ± 26 | 294 ± 13 | 128 ± 11 | 66 ± 6 | |
Antibiotic + MDR infected group | 391 ± 10∗ | 195 ± 14∗ | 110 ± 11∗ | 78 ± 4∗ | ND | ||
Antibiotic + SS infected group | 395 ± 16∗ | 193 ± 14∗ | 112 ± 6∗ | 81 ± 6∗ | ND | ||
Antibiotic + MDR infected group fed on thyme microemulsion | 387 ± 13∗ | 188 ± 6∗ | 104 ± 12∗ | 74 ± 5∗ | ND | ||
Antibiotic + SS infected group fed on thyme microemulsion | 386 ± 19∗ | 187 ± 12∗ | 103 ± 10∗ | 75 ± 4∗ | ND |
ND: not detected. ∗Significant with normal healthy group given antibiotic only at the same column using ANOVA at P ≤ 0.05.