Table 2. Summary of the post-non-HA filler granuloma presentation and outcome.
| Author (first author) | Year | Country | Age | Sex | Type of filler | Site of injection (lips) | Onset (time after injection, months) | Final treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| Wang 33 | 2018 | United States | 63 | F | Silicone | Upper lip, NLF | 36 | Surgical | Resolved |
| Sanchis-Bielsa 12 | 2006 | Spain | 70 | F | Collagen | Upper lip, NLF | 12 | Systemic steroids | Resolved |
| 43 | F | Silicone | Both lips | 30 | Systemic steroids | Resolved | |||
| Schmidt-Westhausen 34 | 2004 | Germany | 56 | F | Silicone | Lower lip | 12 | Surgical | Resolved |
| Hamilton 35 | 2008 | France | 58 | F | PLLA | Both lips | 18 | Intralesional steroids | Resolved |
| Dijkema 36 | 2005 | Netherlands | 64 | F | PLLA | Upper lip | 14 | Surgical | Not reported |
| Bigatà 37 | 2001 | Spain | 30 | F | Silicone | Lips (unspecified) | 8 | NSAIDs, systemic and intralesional steroids | Resolved |
| Maly 38 | 2002 | Israel | 32 | F | Silicone | Upper lip | 24 | – | Not reported |
| Ficarra 16 | 2009 | Multiple | 5656 | F | Silicone | Both lips | 120 | NSAIDs, systemic steroids | Persistent |
| 34 | M | Silicone | Upper lip | 84 | Surgical | Resolved | |||
| 50 | F | Silicone | Lower lip | 60 | Intralesional steroids | Stable (asymptomatic and no change) | |||
| 39 | F | Silicone | Lower lip | 84 | Surgical | Stable | |||
| 38 | F | Silicone | Lower lip | 60 | Surgical | Resolved | |||
| 52 | F | Silicone | Upper lip | 12 | Surgical | Lost to follow-up | |||
| 77 | F | Silicone | Upper lip | 180 | Surgical | Lost to follow-up | |||
| Alijotas-Reig 39 | 2009 | Spain | 65 | F | PLLA | Both lips, NLF | 15 | HCQ, systemic steroids, NSAIDs | Remission |
| 60 | F | PLLA | Both lips, NLF | 60 | Intralesional steroids, HCQ, allopurinol, prednisone, minocycline | Minor bouts | |||
| 48 | F | PLLA | Lips (unspecified) | 10 | Intralesional steroids | Remission | |||
| 39 | F | PLLA | Lips (unspecified) | 6 | Intralesional steroids, NSAIDs | Recurrent bouts | |||
| 59 | F | PLLA | Both lips, NLF | 17 | Intralesional steroids, NSAIDs | Remission | |||
| Akrish 40 | 2009 | Israel | 41 | F | PAIG | Lips (unspecified) | 12 | Surgical | Not reported |
| 43 | F | PAIG | Upper lip | − | Surgical | Not reported | |||
| Baumann 41 | 2003 | United States | 31 | F | Silicone | Both lips | 6 | Imiquimod topical cream | Resolved |
| Da Costa Miguel 42 | 2009 | Brazil | 56 | F | PMMA | Lips (unspecified) | 12 | Surgical | Not reported |
| Dionyssopoulos 7 | 2007 | Multiple | 45 | F | PLLA | Both lips | 4 | Intralesional steroids | Significant volume reduction, granulomas not completely resorbed |
| Friedmann 43 | 2016 | Multiple | 46 | F | Silicone | Both lips, NLF | 12 | Intralesional 5-FU | Significant reduction in lesion size/firmness |
| 47 | F | Silicone | Upper lip | 120 | Intralesional 5-FU | Progressive improvement | |||
| Weyand 44 | 2008 | Germany | 62 | F | Mixed (HA + HEMA + EMA) | Lips (unspecified) | 0 | Surgical, antibiotics, intralesional steroids | Persisted (physical + psychological complications) |
| Grippaudo 9 | 2014 | Italy | 28 | F | Silicone | Lips (unspecified) | 12 | Antibiotics | Resolved |
| 58 | F | Mixed (silicone + HA + EMA + HEMA) | Lips (unspecified) | – | Antibiotics | Resolved | |||
| 34 | F | PAAG | Lips (unspecified) | 0.25 | Surgical | Resolved | |||
| 45 | F | PAAG | Lips (unspecified) | 24 | Antibiotics, surgical | Resolved | |||
| 55 | F | PAAG | Lips (unspecified) | 0.25 | Antibiotics, surgical | Resolved | |||
| 43 | F | PAAG | Lips (unspecified) | 72 | Surgical | Resolved | |||
| 40 | F | PAAG | Lips (unspecified) | 36 | Antibiotics, surgical | Resolved | |||
| 32 | F | Mixed | Lips (unspecified) | 12 | Antibiotics | Resolved | |||
| 48 | F | Mixed | Lips (unspecified) | 60 | Antibiotics, surgical | Resolved | |||
| 45 | F | Collagen | Lips (unspecified) | 12 | Systemic steroids | Resolved | |||
| 38 | F | PAIG | Lips (unspecified) | 60 | Systemic steroids | Resolved | |||
| 73 | F | PAIG | Lips (unspecified) | 36 | Filler for asymmetry | Resolved | |||
| 28 | F | PAIG | Lips (unspecified) | 24 | Surgical | Resolved | |||
| 55 | F | PAIG | Lips (unspecified) | 60 | Antibiotics, surgical | Resolved | |||
| Sanchis-Bielsa 12 | 2009 | Spain | 63 | F | Silicone | Lips (unspecified) | 168 | Systemic steroids | Partial healing |
| 70 | F | Collagen | Lips (unspecified) | 24 | Systemic steroids | Resolved | |||
| 71 | F | Silicone | Lips (unspecified) | 2 | Systemic steroids | Not resolved | |||
| 54 | F | Silicone | Lips (unspecified) | 1 | Systemic steroids | Partial healing | |||
| Martin 45 | 2018 | United Kingdom | 24 | F | HA (unspecified) | Upper lip | NA | NA | NA |
| 43 | F | HA (unspecified) | Upper lip | NA | NA | NA | |||
| 67 | F | HA + acrylic | Lower lip | NA | NA | NA | |||
| 62 | F | HA + acrylic | Upper lip | NA | NA | NA | |||
| 44 | F | Silicone | Lower lip | NA | NA | NA | |||
| 36 | F | CaHA | Lower lip | NA | NA | NA | |||
| 48 | F | Collagen | Lower lip | NA | NA | NA | |||
| 36 | F | Silicone | Upper lip | NA | NA | NA |
Abbreviations: CaHA, calcium hydroxyapatite; EMA, ethyl-methacrylate; F, female; FU, fluorouracil; HA, hyaluronic acid; HEMA, hydroxyl-ethyl-methacrylate; M, male; NA, not available or reported; PAAG, polyacrylamide gel; PAIG, polyalkylimide gel; PLLA, poly-L-lactic acid; PMMA, polymethylmethacrylate.