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. 2022 Feb 17;10:845461. doi: 10.3389/fcell.2022.845461

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Copyright © 2022 Filova, Bohuslavova, Tavakoli, Yamoah, Fritzsch and Pavlinkova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Efficient elimination of Neurod1 by Foxg1-Cre is shown in delaminating neuroblasts and the inner ear ganglion. Cre recombinase (red) was detected as early as E9.5 in mouse Foxg1 ^Cre/+ otocyst (A,B,E,F). Neurod1 (white) is eliminated using Foxg1^Cre in mutants at E9.5 (J) as well as at E10.5 (L), while in controls, NEUROD1 is expressed in delaminating neurons (I,K) that are co-labeled by Isl1 antibody (green; M–P). The area of the inner ear ganglion is delineated by the dotted line. Scale bars: 50 µm. GG, geniculate ganglion; HS, Hoechst nuclear staining; IEG, inner ear/otic ganglion.