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. 2022 Feb 17;10:845461. doi: 10.3389/fcell.2022.845461

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Copyright © 2022 Filova, Bohuslavova, Tavakoli, Yamoah, Fritzsch and Pavlinkova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The sensory epithelium of the cochlea is disorganized in Neurod1CKO. (A–D) In contrast to adult controls, the sensory epithelium in the base of Neurod1CKO has missing cells (asterisks), as shown by confocal images of immunolabeling with inner hair cell (IHC) marker calretinin and with prestin, a marker of outer hair cells (OHCs). Ectopic (transdifferentiated) IHCs located among OHCs, two IHC rows, and multiple OHC rows are found in the Neurod1CKO apex compared to the single row of IHCs and three rows of OHCs in control cochlea. (E,F) Scanning electron microscopy revealed abnormalities in the cellular characteristics and hair cell stereocilia organization in Neurod1CKO. Compared to the control epithelium, HCs in the Neurod1CKO cochlea differed in their size (asterisk marks a fused cell), the orientation of cells, and stereocilia. IHCs are pseudocoloured blue. Scale bars: 20 µm (A–D); 5 μm (E,F).