Fig.2. Therapeutic effects of SH and CDP on hepatic steatosis and dyslipidemia in HFD-fed ApoE ^−/− mice .

Hepatic protein and 5-HT levels in the liver and serum (a), TG, VLDL, and HDL levels in liver (b), representative color photo of liver and histopathological findings of hepatic lipid droplets determined by oil red O staining (20×), and hepatic index (c), and serum levels of TG, FFAs, oxLDL (d), TC, LDL-c, VLDL-c, and HDL-c (e) in control (Ctrl) and HFD-fed ApoE ^−/− with or without SH and CDP treatment (alone or in combination) mice. Data are presented as the mean±SD of four mice chosen randomly for the examination of protein expression and of eight mice for the measurement of other indicators in each group. ^＊ P ＜0.05, ^＊＊ P ＜0.01. Abbreviations: NS, not significant; SH, sarpogrelate hydrochloride; CDP, carbidopa; CP, cytoplasm; PM, plasmalemma