Fig. 1.
Sequence and structure of KRASG12C–AMG 510 complex. (A). Multiple sequence alignment of three RAS proteins (KRAS, HRAS, and NRAS), including the catalytic domains and HVRs. (B) Cartoon and surface representations of the KRASG12C–AMG 510 complex (PDB entry: 6OIM). The SI, SII, HVR, SII-P, and residue C12 are colored as magenta, orange, purple, yellow, and red, respectively. (C) The chemical structure of AMG 510. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)