Fig. 4.
Correlated motions of residue pairs in KRASG12C. (A) Combination of residue pair cross-correlation matrices between KRASG12C-apo (upper left triangle) and KRASG12C-AMG 510 (lower right triangle). The strength of cross-correlation is colored ranging from red (for Cij ≥ 0, lockstep motions) to blue (for Cij ≤ 0, anti-correlated motions). The enlarged plots of residue pair cross-correlations between switch-I (residues 30–38) and switch-II (residues 59–76) in KRASG12C-apo and KRASG12C-AMG 510 are shown in panels B and C, respectively. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)