Table 2.

Binding energy change of AMG 510 interacting with various KRAS^G12C mutants.

	△G (kcal/mol)a	△△G (kcal/mol)b
KRASG12C	−51.664	0.000
KRASG12C/K16A	−50.189	1.475
KRASG12C/T35A	−37.934	13.730
KRASG12C/Q61A	−43.118	8.547
KRASG12C/R68A	−40.793	10.872
KRASG12C/H95A	−45.988	5.676
KRASG12C/Y96A	−32.879	18.786
KRASG12C/Q99A	−48.376	3.288
KRASG12C/V103A	−43.114	8.550

^aThe binding energy of AMG 510 interacting with protein single mutant (i.e. KRAS^G12C) or double mutants (KRAS^{G12C/mutations}).

^bThe binding energy change of double mutants relative to single mutant (i.e. KRAS^G12C).