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. 2021 Dec 23;32(1):239–248. doi: 10.1007/s00062-021-01129-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — VSI maps shown using the NORA medical imaging platform in patients with a glioblastoma multiforme, b primary CNS lymphoma, c metastatic lung cancer. Left: post-contrast T1-weighted images showing enhancement of tumor regions. Middle: corresponding mean vessel diameter (vsi) maps. Right: corresponding microvessel density (Q) maps. Tumor regions show elevated mean vessel diameters with decreased microvessel densities compared to healthy tissues