TABLE 1.

IC₅₀ and CC₅₀ of formycin A, SMeFM, and T-705 for the propagation of influenza virus strains and for cell viability.

Compound	Strain	Cell	IC50 (nM)*	CC50 (μM)#
Formycin A	A/WSN/33	MDCK	37.3 ± 21.5
		MDCK		2.77 ± 0.17
SMeFM	A/WSN/33	MDCK	34.1 ± 27.4
	A/equine/2/Miami/63	MDCK	43.8 ± 27.7
	B/Lee/40	MDCK	37.9 ± 26.6
		MDCK		14.6 ± 9.7
	A/WSN/33	A549	52.4 ± 1.1
		A549		20.8 ± 7.7
	A/WSN/33	Calu-3	24.4 ± 6.3
		Calu-3		145.8 ± 41.5
T-705	A/WSN/33	MDCK	200.3 ± 11.7
		MDCK		>1,000

*The half-maximal inhibitory concentration (IC₅₀) was determined from the result of the plaque assay. Average values with standard deviations from three independent experiments were shown.

^#The half-maximal cytotoxic concentration (CC₅₀) was determined from the result of the MTS assay.

Average values with standard deviations from three independent experiments were shown.