Table 3.

Evolution over time in the 11 patients of the DBS group who completed the study

	Pre-operatively meds only	6 months	6 years	12 years	Difference pre-op—6 months	Difference pre-op—12 years
Best UPDRS III on meds, on DBS	17 ± 8.2	17.5 ± 5.6	21.3 ± 7.8	24.2 ± 11.2	p = 0.92	p = 0.17
Worst UPDRS III on meds, on DBS	54 ± 9.92	28.8 ± 7.3	31.1 ± 8.3	62 ± 13.1	p = 0.01	p = 0.92
LEDD mg	1032 ± 144	483 ± 86	552 ± 76	655 ± 132	p < 0.001	p = 0.01

Significant differences in bold, two-tailed ANOVA + post hoc Bonferroni corrections for repeated time measurements. See text for details of patients’ conditions