Table 3.
Univariate and multivariate Cox regression models in young (age ≤ 40 years) male ACLF patients.
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Variables | HR (95% CI for HR) | p.value | HR (95% CI for HR) | p.value |
| Age (years) |
1.040 (0.932–1.160) |
0.493 | ||
| Cirrhosis | 3.360 (0.910–12.400) |
0.069 | ||
| BMI (kg/m2) |
0.977 (0.856–1.120) |
0.730 | ||
| Obesity | 0.927 (0.294–2.920) |
0.897 | ||
| ALB (g/L) |
0.942 (0.858–1.030) |
0.205 | ||
| TB (mg/dL) |
1.070 (1.010–1.130) |
0.021 | ||
| INR | 3.880 (1.610–9.380) |
0.003 | ||
| CR (mg/dL) |
5.460 (0.283–105.000) |
0.261 | ||
| Na (mmol/L) |
0.859 (0.783–0.941) |
0.001 | ||
| WBC (*109/L) |
0.955 (0.859–1.060) |
0.391 | ||
| PLT (*109/L) |
0.991 (0.980–1.000) |
0.088 | ||
| HGB (g/L) |
0.982 (0.961–1.000) |
0.088 | ||
| MELD score | 1.430 (1.190–1.720) |
0.000 | 1.381 (1.137–1.676) |
0.001 |
| Ascites | 0.025 (0.000–3.770) |
0.150 | ||
| HE | 3.700 (1.170–11.700) |
0.026 | ||
| PMI (cm2/m2) |
0.745 (0.557–0.997) |
0.048 | 0.689 (0.496–0.958) |
0.027 |
The multivariate logistic regression model was fited with a stepwise selection method. Considering that there are too few dependent variables in our study, to avoid over fitting the model, according to the previous research results and clinical constraints, select MELD and PMI for multivariate analysis. BMI, body mass index; ALB, albumin; TB, total bilirubin; INR, International normalized ratio; CR, Serum creatinine; Na, Serum sodium; WBC, White blood cell count; PLT, platelet; HGB, hemoglobin; MELD, model for end-stage liver disease; HE, Hepatic encephalopathy; PMI, psoas muscle index.